1996
Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells
Markham R, Schwartz D, Templeton A, Margolick J, Farzadegan H, Vlahov D, Yu X. Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells. Journal Of Virology 1996, 70: 6947-6954. PMID: 8794338, PMCID: PMC190744, DOI: 10.1128/jvi.70.10.6947-6954.1996.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 variantsHu-PBLSCID miceType 1 variantsPrimary isolatesNSI variantsSCID mouse model systemPeripheral blood mononuclear cellsBlood mononuclear cellsHIV-1 variantsMT-2 cellsMouse model systemMononuclear cellsRelative infectiousnessCell culturesVaccine developmentClinical settingMiceEnv sequencesMonoclonal cellsTissue culture systemCellsIsolatesCulture systemPreferential transmission
1995
Identification of Human Immunodeficiency Virus Primary Isolates Resistant to Interferon-α and Correlation of Prevalence to Disease Progression
Kiinzi M, Farzadegan H, Margolick J, Vlahov D, Pitha P. Identification of Human Immunodeficiency Virus Primary Isolates Resistant to Interferon-α and Correlation of Prevalence to Disease Progression. The Journal Of Infectious Diseases 1995, 171: 822-828. PMID: 7706808, DOI: 10.1093/infdis/171.4.822.Peer-Reviewed Original ResearchConceptsCD4 cell numbersHIV infectionIFN-alphaLow CD4 cell numbersSerum IFN-alpha levelsHuman immunodeficiency virusIFN-alpha levelsEndogenous IFN-alphaAbsence of AIDSCourse of infectionCell numberCorrelation of prevalenceIFN-alpha 2Immunodeficiency virusDisease progressionPrimary isolatesCell tropismResistant variantsAlpha 2InfectionAIDSPrevalenceFavor survivalSequential analysisIsolates