2013
Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population
Manini A, Jacobs M, Vlahov D, Hurd Y. Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population. Journal Of Medical Toxicology 2013, 9: 148-154. PMID: 23318993, PMCID: PMC3648633, DOI: 10.1007/s13181-012-0286-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternative SplicingAmino Acid SubstitutionBenzodiazepinesCohort StudiesDrug OverdoseFemaleFollow-Up StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHeart ArrestHumansMaleNarcoticsPilot ProjectsPolymorphism, Single NucleotideProspective StudiesReceptors, Opioid, muRespiratory InsufficiencySeverity of Illness IndexSympathomimeticsUnited StatesConceptsAcute drug overdoseG variant alleleClinical severityVariant allelesEmergency departmentDrug overdoseSingle nucleotide polymorphismsConsecutive adult ED patientsHuman mu-opioid receptor geneReceptor single nucleotide polymorphismsWorse clinical severityAdult ED patientsObservational cohort studyUrban teaching hospitalMu-opioid receptor geneAbove single nucleotide polymorphismsCohort studyED patientsRespiratory arrestCardiac arrestClinical variablesAcute drugSevere outcomesTeaching hospitalBlood samples
2007
Identifying injection drug users at risk of nonfatal overdose.
Coffin P, Tracy M, Bucciarelli A, Ompad D, Vlahov D, Galea S. Identifying injection drug users at risk of nonfatal overdose. Academic Emergency Medicine 2007, 14: 616-23. PMID: 17554010, DOI: 10.1197/j.aem.2007.04.005.Peer-Reviewed Original ResearchConceptsDrug usersHabitual drug usersNonfatal overdoseAggressive prevention effortsAgonist maintenance treatmentSerious withdrawal symptomsInjection drug usersFurther longitudinal studiesIndividual-level risk factorsTake-home naloxoneOverdose prevention interventionsFuture overdosesMaintenance treatmentWithdrawal symptomsRisk factorsDrug overdoseRecent overdoseEmergency physiciansOverdose riskPrevention interventionsHigh riskOverdoseMedical careYounger ageU.S. adults
2000
Increased Frequency of Overdose Deaths Among HIV-Infected Injection Drug Users
Vlahov D, Tang A, Lyles C, Rezza G, Thomas D, Cohn S, Macalino G, Stambolis V, Nelson K. Increased Frequency of Overdose Deaths Among HIV-Infected Injection Drug Users. Addiction Research & Theory 2000, 8: 311-326. DOI: 10.3109/16066350009009518.Peer-Reviewed Original ResearchInjection drug usersCause-specific mortalityHTV infectionOverdose deathsDrug usersUninfected personsPerson-time techniquesOverall mortality rateFrequency of AIDSOnset of AIDSCorrelates of deathMedian ageHIV serostatusPerson yearsExcess riskDrug overdoseMortality ratePoisson regressionRecord searchUnderlying causeInfectionMortalityDeathAIDSBaseline
1994
Suspected determinants of enrollment into detoxification and methadone maintenance treatment among injecting drug users
Schütz C, Rapiti E, Vlahov D, Anthony J. Suspected determinants of enrollment into detoxification and methadone maintenance treatment among injecting drug users. Drug And Alcohol Dependence 1994, 36: 129-138. PMID: 7851280, DOI: 10.1016/0376-8716(94)90095-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmphetamineBaltimoreCocaineCross-Sectional StudiesFemaleFollow-Up StudiesHeroin DependenceHIV InfectionsHumansMaleMethadoneMiddle AgedOpioid-Related DisordersPatient Acceptance of Health CarePatient AdmissionProspective StudiesRisk FactorsSocial EnvironmentSubstance Abuse, IntravenousSubstance-Related DisordersUrban PopulationConceptsMethadone maintenance treatmentMethadone maintenance programDrug usersIndependent predictorsMaintenance treatmentMultiple logistic regression analysisLogistic regression analysisProspective study designTime of recruitmentActive drug usersCross-sectional investigationIDU participantsMethadone maintenanceDrug overdoseNext followDetoxification programCommunity outreach effortsTreatment settingsPrior treatmentDrug useDetoxification treatmentStudy designUntreated drug usersTreatmentRegression analysis