Probing the effect of promoters on noise in gene expression using thousands of designed sequences
Sharon E, van Dijk D, Kalma Y, Keren L, Manor O, Yakhini Z, Segal E. Probing the effect of promoters on noise in gene expression using thousands of designed sequences. Genome Research 2014, 24: 1698-1706. PMID: 25030889, PMCID: PMC4199362, DOI: 10.1101/gr.168773.113.Peer-Reviewed Original ResearchConceptsExpression noiseGene expressionMean expression levelTranscription factorsPromoter sequencesExpression levelsGene expression noisePromoter DNA sequencesMore transcription factorsNucleosome-disfavoring sequencesHigher expression noiseDifferent promoter sequencesNonspecific DNA bindingOne-dimensional slidingCellular functionsHigh-throughput methodNative promoterDNA sequencesDNA bindingSynthetic promotersPromoterIdentical cellsTarget siteSequence