2015
Noise in gene expression is coupled to growth rate
Keren L, van Dijk D, Weingarten-Gabbay S, Davidi D, Jona G, Weinberger A, Milo R, Segal E. Noise in gene expression is coupled to growth rate. Genome Research 2015, 25: 1893-1902. PMID: 26355006, PMCID: PMC4665010, DOI: 10.1101/gr.191635.115.Peer-Reviewed Original ResearchConceptsGene expression noiseExpression noiseGene expressionGlobal changeLower growth rateDifferent growth ratesDifferent cell cycle stagesAverage gene expressionNutrient-poor conditionsEnvironmental conditionsCell cycle stageOverall high variabilityGrowth rateMost promotersCell cycle heterogeneityCellular regulationPromoter featuresDisplay elevated levelsExpression variabilityBiological functionsExpression distributionPhenotypic implicationsAsynchronous populationIdentical cellsExpression values
2013
Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise
Dadiani M, van Dijk D, Segal B, Field Y, Ben-Artzi G, Raveh-Sadka T, Levo M, Kaplow I, Weinberger A, Segal E. Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise. Genome Research 2013, 23: 966-976. PMID: 23403035, PMCID: PMC3668364, DOI: 10.1101/gr.149096.112.Peer-Reviewed Original ResearchConceptsPromoter dynamicsExpression variabilityPromoter transitionsSingle-cell time-lapse microscopyInactive stateSequence changesNucleosome-disfavoring sequencesCis-regulatory elementsProcess of transcriptionActive stateNumber of transcriptsTime-lapse microscopyCell populationsTranscriptional noiseTranscriptional dynamicsSite resultsTranscription factorsDNA sequencesGene expressionMean expressionIdentical populationsIndividual cellsSequence resultsExpression levelsTranscripts