Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage
van Dijk D, Dhar R, Missarova AM, Espinar L, Blevins WR, Lehner B, Carey LB. Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage. Nature Communications 2015, 6: 7972. PMID: 26268986, PMCID: PMC4557116, DOI: 10.1038/ncomms8972.Peer-Reviewed Original ResearchConceptsTranscriptional stress responseDNA damageDNA damage responseIsogenic populationsRNA polymerase fidelityDamage responseTranscriptional differencesIsogenic cellsEnvironmental stressCell variabilityStress responseGrowth ratePolymerase fidelityCulture conditionsPolymerase error rateOxidative stressCellsSuch cellsSame environmentTranscriptomeTransposonSubpopulationsTranscriptsGenotypicStress