2024
Evaluating Operative Exposure for Medical Students in the Era of Virtual Learning: A Single-Institution Experience
Rivero R, Brown L, Flom E, Morton C, Esdaille C, Jernigan E, Lui F, Stitelman D. Evaluating Operative Exposure for Medical Students in the Era of Virtual Learning: A Single-Institution Experience. Journal Of Surgical Education 2024, 81: 1346-1351. PMID: 39163718, DOI: 10.1016/j.jsurg.2024.07.015.Peer-Reviewed Original ResearchGeneral surgery casesSurgical casesSurgery casesOperating roomSurgical clerkshipSingle-institution experienceMedical studentsClerkship studentsOperating room casesTertiary centerSurgical electivesSurgery exposureInguinal herniaLung cancerSurgical rotationGeneral surgerySurgical teamSkin cancerSurgical specialtiesClinical trainingOperative exposureRoom experienceClerkship directorsClerkshipCancerPrenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Rivero R, Stitelman D. Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery. Current Stem Cell Reports 2024, 10: 51-57. DOI: 10.1007/s40778-024-00237-8.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaDiaphragmatic herniaAnimal modelsIntra-amniotic injectionLong-term functional outcomeParticle-based deliveryFetal therapyPrenatal therapySpinal defectsTarget specific tissuesCo-morbiditiesCongenital diseaseFunctional outcomesTreatment deliveryStructural diseaseClinical translationMyelomeningoceleTherapyHerniaSpecific tissuesTissueDiseaseDeliveryPrenatallyParticle deliveryThe Technical and Ethical Framework of Fetal Therapy: Past and Current Advances
Lynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. DOI: 10.1007/s40778-024-00235-w.Peer-Reviewed Original ResearchFetal drug deliverySuccess of nanomedicineDrug deliveryPharmacological drug treatmentsMinimally invasive strategyFetal therapyFetal applicationsClinical studiesCongenital diseaseInvasive strategyDrug treatmentClinical translationClinical practiceTherapyMedical interventionsDeliveryFetalNanomedicineBirthDiseaseFindingsAClinicians
2023
Ovarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient
Roth L, Smith A, Buza N, Coons B, Stitelman D, Vash-Margita A. Ovarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient. Journal Of Pediatric And Adolescent Gynecology 2023, 37: 217-219. PMID: 38110028, DOI: 10.1016/j.jpag.2023.11.014.Peer-Reviewed Original ResearchPolycystic ovarian syndromeOvarian tumorsCell tumorsRecurrent ovarian torsionAbnormal uterine bleedingPost-menopausal womenLeydig cell tumorUterine bleedingOvarian syndromeOvarian torsionYounger patientsOvarian functionOvarian hilumAdolescent patientsNodular proliferationSecrete androgensTumor AssociatedRecurrent torsionPrimary amenorrheaCurrent recommendationsReinke crystalsTumorsLeydig cellsIncidence increasesVirilizationIn utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia
Ullrich S, Yung N, Bauer-Pisani T, Maassel N, Guerra M, Freedman-Weiss M, Ahle S, Ricciardi A, Sauler M, Saltzman W, Piotrowski-Daspit A, Stitelman D. In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia. Molecular Therapy - Nucleic Acids 2023, 32: 594-602. PMID: 37200861, PMCID: PMC10185702, DOI: 10.1016/j.omtn.2023.04.018.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaTGF-β pathwayDiaphragmatic herniaFetal ratsPulmonary vascular remodelingLung function resultsGestational day 18Pre-clinical modelsDifferent gestational timesCritical illnessPulmonary pathologyLung growthLung sizeRat modelFetal casesLung morphologyVascular remodelingMicroRNA-200bVein injectionFetal diseaseFirst breathDay 18Lung developmentGestational timeInvasive fashion
2022
Cholecystitis and Gallstone Disease
Maassel N, Stitelman D. Cholecystitis and Gallstone Disease. 2022, 837-841. DOI: 10.1007/978-3-031-07524-7_90.Peer-Reviewed Original ResearchLow gallbladder ejection fractionLimited hospital stayMost surgical candidatesPediatric laparoscopic cholecystectomyAbsence of gallstonesGallbladder ejection fractionNuclear medicine scansTreatment of childrenBiliary colicBiliary dyskinesiaHospital stayComplicated cholecystitisSurgical candidatesEjection fractionGallstone diseaseLaparoscopic cholecystectomyMotility disordersBlood testsPhysical examinationChronic hemolytic diseaseHemolytic diseaseFocused historyPediatric specialistsObesity ratesCholecystitisPrenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI‐FDA Meeting)
Herzeg A, Almeida‐Porada G, Charo RA, David AL, Gonzalez‐Velez J, Gupta N, Lapteva L, Lianoglou B, Peranteau W, Porada C, Sanders SJ, Sparks TN, Stitelman DH, Struble E, Sumner CJ, MacKenzie TC. Prenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI‐FDA Meeting). The Journal Of Clinical Pharmacology 2022, 62: s36-s52. PMID: 36106778, PMCID: PMC9547535, DOI: 10.1002/jcph.2127.Peer-Reviewed Original ResearchSurface conjugation of antibodies improves nanoparticle uptake in bronchial epithelial cells
Luks VL, Mandl H, DiRito J, Barone C, Freedman-Weiss MR, Ricciardi AS, Tietjen GG, Egan ME, Saltzman WM, Stitelman DH. Surface conjugation of antibodies improves nanoparticle uptake in bronchial epithelial cells. PLOS ONE 2022, 17: e0266218. PMID: 35385514, PMCID: PMC8986008, DOI: 10.1371/journal.pone.0266218.Peer-Reviewed Original ResearchConceptsTarget-specific antibodiesNanoparticle uptakeSurface conjugationNanoparticle surface modificationSurface of nanoparticlesCellular uptakeSite-specific geneSpecific cellular bindingNanoparticlesIntracellular deliveryEditing reagentsBronchial epithelial cellsSurface modificationCellular targetingCystic fibrosisTherapeutic agentsEpithelial cellsParticle uptakeFeasible strategyGenetic diseasesFirst demonstrationHuman bronchial epithelial cellsKinetics of antibodiesCellular bindingAppropriate antibodiesIntra-amniotic Injection of Poly(lactic-co-glycolic Acid) Microparticles Loaded with Growth Factor: Effect on Tissue Coverage and Cellular Apoptosis in the Rat Model of Myelomeningocele.
Maassel NL, Wu DH, Yung NK, Bauer-Pisani T, Elizabeth Guerra M, Ullrich SJ, Mark Saltzman W, Stitelman DH. Intra-amniotic Injection of Poly(lactic-co-glycolic Acid) Microparticles Loaded with Growth Factor: Effect on Tissue Coverage and Cellular Apoptosis in the Rat Model of Myelomeningocele. Journal Of The American College Of Surgeons 2022, 234: 1010-1019. PMID: 35703790, DOI: 10.1097/xcs.0000000000000156.Peer-Reviewed Original ResearchConceptsSoft tissue coverageIntra-amniotic injectionFibroblast growth factorTissue coverageRat modelMMC defectsGrowth factorCellular apoptosisGestational day 17Spinal cord cellsSitu cell deathCell deathWild-type controlsHistologic evidenceTreatment optionsLifelong morbidityUtero treatmentNeurologic disordersRat damsCord cellsMyelomeningoceleDay 17Invasive platformIncidenceInjection
2021
Firework-related injuries treated at emergency departments in the United States during the COVID-19 pandemic in 2020 compared to 2018–2019
Maassel N, Saccary A, Solomon D, Stitelman D, Xu Y, Li F, Christison-Lagay E, Dodington J. Firework-related injuries treated at emergency departments in the United States during the COVID-19 pandemic in 2020 compared to 2018–2019. Injury Epidemiology 2021, 8: 65. PMID: 34758871, PMCID: PMC8579722, DOI: 10.1186/s40621-021-00358-2.Peer-Reviewed Original ResearchNational Electronic Injury Surveillance SystemFireworks-related injuriesEmergency departmentElectronic Injury Surveillance SystemNational estimatesConsumer Product Safety Commission dataInjury Surveillance SystemCOVID-19 pandemicStudy inclusionInjury informationInjuryMonthly injurySame time periodUS Census dataNational decreaseMonthsSurveillance systemConsumer fireworksUnited StatesProportional increaseYearsDepartmentPandemicResultsThereEpidemiologyInstitutional Variation in Gastrostomy Tube Placement After Duodenal Atresia Repair in Children With Trisomy 21
Maassel NL, Guerra ME, Solomon DG, Stitelman DH. Institutional Variation in Gastrostomy Tube Placement After Duodenal Atresia Repair in Children With Trisomy 21. Journal Of Pediatric Gastroenterology And Nutrition 2021, 73: 560-565. PMID: 34238829, DOI: 10.1097/mpg.0000000000003227.Peer-Reviewed Original ResearchConceptsPediatric Health Information SystemGastrostomy tube placementDuodenal atresiaGastrostomy tubeGastrostomy placementTube placementTrisomy 21Index admissionIntestinal bypassDiagnostic codesAtresia repairICD-10 diagnostic codesDuodenal atresia repairPost-operative managementInstitutional practice patternsLength of stayProcedure codesBaseline characteristicsRetrospective reviewPractice patternsPatientsHealth information systemsGastrostomyNeonatesAdmissionDiffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele
Maassel N, Farrelly J, Coman D, Freedman-Weiss M, Ahle S, Ullrich S, Yung N, Hyder F, Stitelman D. Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele. PLOS ONE 2021, 16: e0253583. PMID: 34191842, PMCID: PMC8244849, DOI: 10.1371/journal.pone.0253583.Peer-Reviewed Original ResearchConceptsMagnetic resonance imaging techniquesSpinal cordRat fetusesRetinoic acidCommon congenital anomalyComplementary imaging biomarkerLack of skinNeural tube defectsTrans retinoic acidBony coveringRat damsCongenital anomaliesRat modelExperimental therapiesHistopathologic analysisSevere formBrain volumeMyelomeningoceleImaging biomarkersDisease severityMMC defectsTube defectsIncomplete closureFetusesFractional anisotropy (FA) mapsA narrative review of in utero gene therapy: advances, challenges, and future considerations
Yung NK, Maassel NL, Ullrich SJ, Ricciardi AS, Stitelman DH. A narrative review of in utero gene therapy: advances, challenges, and future considerations. Translational Pediatrics 2021, 10: 1486496-1481496. PMID: 34189107, PMCID: PMC8192997, DOI: 10.21037/tp-20-89.Peer-Reviewed Original ResearchHighest effective doseGene therapyPathogenesis increasesLysosomal storage disorderImmune tolerancePostnatal treatmentTreatment optionsClinical trialsAnimal modelsCystic fibrosisFetal diagnosisNarrative reviewTranslational gapEffective doseUtero gene therapyPhysiologic phenomenonStorage disorderDiseaseNext-generation sequencingIUGTTechnologic advancementsCandidate diseaseClinical realmTherapyPotential diseaseEngineering alginate microparticles for optimized accumulation in fetal rat myelomeningocele
Freedman-Weiss MR, Wu D, Maassel N, Ullrich SJ, Ahle SL, Roberts K, Farrelly JS, Buzzelli G, Saltzman WM, Stitelman DH. Engineering alginate microparticles for optimized accumulation in fetal rat myelomeningocele. Journal Of Pediatric Surgery 2021, 57: 544-550. PMID: 33933264, DOI: 10.1016/j.jpedsurg.2021.03.060.Peer-Reviewed Original ResearchThe parental journey of fetal care: a systematic review and metasynthesis
Wilpers A, Bahtiyar MO, Stitelman D, Batten J, Calix RX, Chase V, Yung N, Maassel N, Novick G. The parental journey of fetal care: a systematic review and metasynthesis. American Journal Of Obstetrics & Gynecology MFM 2021, 3: 100320. PMID: 33493706, DOI: 10.1016/j.ajogmf.2021.100320.Peer-Reviewed Original ResearchNanoparticles for delivery of agents to fetal lungs
Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Nanoparticles for delivery of agents to fetal lungs. Acta Biomaterialia 2021, 123: 346-353. PMID: 33484911, PMCID: PMC7962939, DOI: 10.1016/j.actbio.2021.01.024.Peer-Reviewed Original ResearchConceptsFetal lungCellular uptakeIntra-amniotic routeRoute of deliveryCongenital lung diseaseDelivery of agentsIntra-amniotic deliveryRelative cellular uptakeNanoparticlesFetal treatmentDiaphragmatic herniaLung diseaseFetal therapyLung tissueFetal miceIntravenous deliveryCystic fibrosisLungLung therapyInterventional technologiesTherapeutic agentsEndothelial cellsCell populationsEffective targetingTherapy
2020
Anomalies of the Gastrointestinal Tract
Rubinstein J, Farrelly J, Stitelman D, Christison-Lagay E. Anomalies of the Gastrointestinal Tract. 2020, 179-204. DOI: 10.1007/978-3-030-55660-0_9.ChaptersOutcomes following adoption of a standardized protocol for abscess drain management in pediatric appendicitis
Eysenbach LM, Caty MG, Christison-Lagay ER, Cowles RA, Dillon B, Goodman TR, Ozgediz DE, Stitelman DH, Solomon DG. Outcomes following adoption of a standardized protocol for abscess drain management in pediatric appendicitis. Journal Of Pediatric Surgery 2020, 56: 43-46. PMID: 33143877, DOI: 10.1016/j.jpedsurg.2020.09.050.Peer-Reviewed Original ResearchConceptsPediatric appendicitisClinical outcomesStandardized protocolImaging studiesTertiary care children's hospitalEvidence-based clinical pathwayAlternative imaging studyIR proceduresManagement of abscessesRetrospective chart reviewCases of appendicitisPercutaneous abscess drainageInterventional radiologic proceduresDiagnostic imaging studiesComplicated appendicitisBaseline demographicsChart reviewClinical factorsAbscess drainageClinical presentationDrain outputChildren's HospitalDrain daysClinical pathwayAnesthetic administrationThe in-utero diagnosis of choledochal cyst: can postnatal imaging predict benefit from early surgical intervention?
Cochran ED, Lazow SP, Kim AG, Burkhalter LS, Frost NW, Stitelman D, Davis J, Santiago-Munoz P, Buchmiller TL, Perrone EE, Schindel DT. The in-utero diagnosis of choledochal cyst: can postnatal imaging predict benefit from early surgical intervention? The Journal Of Maternal-Fetal & Neonatal Medicine 2020, 35: 1070-1074. PMID: 32188329, DOI: 10.1080/14767058.2020.1742320.Peer-Reviewed Original ResearchConceptsInitial postnatal ultrasoundCholedochal cystCyst sizeEarly surgical interventionEarly complicationsCyst excisionClinical courseFetal centerMedian ageCyst resolutionPostnatal ultrasoundSurgical interventionPrenatal suspicionIRB approvalPatientsUtero diagnosisDiagnostic revisionFirst monthSymptom manifestationCystsNewbornsBirthFirst yearUltrasoundSymptom developmentMinimally Invasive Fetal Therapy for Myelomeningocele
Freedman-Weiss M, Stitelman D. Minimally Invasive Fetal Therapy for Myelomeningocele. Current Stem Cell Reports 2020, 6: 1-5. DOI: 10.1007/s40778-020-00167-1.Peer-Reviewed Original ResearchNon-invasive therapeutic approachInvasive fetal therapyPostnatal surgical repairDevastating clinical manifestationsTissue engineeringScaffold-based tissue engineeringMedical managementSurgical repairCell-based therapiesClinical manifestationsFetal stem cellsCurrent therapiesPatient outcomesSpinal cordFetal therapyFetal surgeryTherapeutic approachesTherapyInvasive wayTranslational scienceStem cellsReview detailsParticle deliveryNovel scientific researchParticle injection