Intra-amniotic Injection of Poly(lactic-co-glycolic Acid) Microparticles Loaded with Growth Factor: Effect on Tissue Coverage and Cellular Apoptosis in the Rat Model of Myelomeningocele.
Maassel NL, Wu DH, Yung NK, Bauer-Pisani T, Elizabeth Guerra M, Ullrich SJ, Mark Saltzman W, Stitelman DH. Intra-amniotic Injection of Poly(lactic-co-glycolic Acid) Microparticles Loaded with Growth Factor: Effect on Tissue Coverage and Cellular Apoptosis in the Rat Model of Myelomeningocele. Journal Of The American College Of Surgeons 2022, 234: 1010-1019. PMID: 35703790, DOI: 10.1097/xcs.0000000000000156.Peer-Reviewed Original ResearchConceptsSoft tissue coverageIntra-amniotic injectionFibroblast growth factorTissue coverageRat modelMMC defectsGrowth factorCellular apoptosisGestational day 17Spinal cord cellsSitu cell deathCell deathWild-type controlsHistologic evidenceTreatment optionsLifelong morbidityUtero treatmentNeurologic disordersRat damsCord cellsMyelomeningoceleDay 17Invasive platformIncidenceInjection