In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia
Ullrich S, Yung N, Bauer-Pisani T, Maassel N, Guerra M, Freedman-Weiss M, Ahle S, Ricciardi A, Sauler M, Saltzman W, Piotrowski-Daspit A, Stitelman D. In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia. Molecular Therapy - Nucleic Acids 2023, 32: 594-602. PMID: 37200861, PMCID: PMC10185702, DOI: 10.1016/j.omtn.2023.04.018.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaTGF-β pathwayDiaphragmatic herniaFetal ratsPulmonary vascular remodelingLung function resultsGestational day 18Pre-clinical modelsDifferent gestational timesCritical illnessPulmonary pathologyLung growthLung sizeRat modelFetal casesLung morphologyVascular remodelingMicroRNA-200bVein injectionFetal diseaseFirst breathDay 18Lung developmentGestational timeInvasive fashion