Histones are Targets for Modification by Glucose‐Derived Methylglyoxal
Galligan J, Mitchener M, Wauchope O, Wang T, Rose K, Spiegel D, Marnett L. Histones are Targets for Modification by Glucose‐Derived Methylglyoxal. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.586.2.Peer-Reviewed Original ResearchDiabetic nephropathyMetabolic memoryHyperglycemia associated with diabetesCause of morbidityMg–HHigh-resolution mass spectrometryDN pathogenesisModel of hyperglycemiaHistone posttranslational modificationsCell culture modelLC-MS/MSDN patientsDiabetic patientsLC-MS/MS methodologyGlycemic controlHEK293 cellsCultured HEK293 cellsPosttranslational modificationsMgO modificationOxidative stressGlyoxalase 1PatientsInflammationMass spectrometryAdducts