2015
Histone reader BRWD1 targets and restricts recombination to the Igk locus
Mandal M, Hamel KM, Maienschein-Cline M, Tanaka A, Teng G, Tuteja JH, Bunker JJ, Bahroos N, Eppig JJ, Schatz DG, Clark MR. Histone reader BRWD1 targets and restricts recombination to the Igk locus. Nature Immunology 2015, 16: 1094-1103. PMID: 26301565, PMCID: PMC4575638, DOI: 10.1038/ni.3249.Peer-Reviewed Original Research
2004
Up-Regulation of Hlx in Immature Th Cells Induces IFN-γ Expression
Zheng WP, Zhao Q, Zhao X, Li B, Hubank M, Schatz DG, Flavell RA. Up-Regulation of Hlx in Immature Th Cells Induces IFN-γ Expression. The Journal Of Immunology 2004, 172: 114-122. PMID: 14688316, DOI: 10.4049/jimmunol.172.1.114.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdoptive TransferAnimalsCD4-Positive T-LymphocytesCell DifferentiationCells, CulturedHemocyaninsHomeodomain ProteinsInjections, IntravenousInjections, SubcutaneousInterferon-gammaInterphaseMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicTh1 CellsT-Lymphocytes, Helper-InducerTranscription FactorsUp-RegulationConceptsCD4 T cellsTransgenic CD4 T cellsTh2-polarizing conditionsTh1 cell differentiationTh cellsT cellsTh1 cellsIFN-gammaKeyhole limpet hemocyanin immunizationNormal CD4 T cellsTime pointsIntracellular cytokine stainingIFN-γ expressionIFN-gamma expressionEarly time pointsCytokine stainingTh2 cellsNaive precursorsCell differentiationSpecific time pointsThymocyte populationTransgenic miceMarked reductionAberrant expressionRetroviral infection