Characterization of TCR gene rearrangements during adult murine T cell development.
Livák F, Tourigny M, Schatz D, Petrie H. Characterization of TCR gene rearrangements during adult murine T cell development. The Journal Of Immunology 1999, 162: 2575-80. PMID: 10072498, DOI: 10.4049/jimmunol.162.5.2575.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Rearrangement, beta-Chain T-Cell Antigen ReceptorGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGene Rearrangement, T-LymphocyteHyaluronan ReceptorsMiceMice, Inbred C57BLPolymerase Chain ReactionReceptors, Interleukin-2T-LymphocytesConceptsTCRbeta locusTCRdelta locusGammadelta T cell lineagesMurine T cell developmentTCR gene rearrangementsT lineage cellsGene rearrangementsT cell developmentLineage decisionsLocus recombinationLineage commitmentProductive rearrangementsIrreversible commitmentCell lineagesDelta geneMolecular evidenceCell developmentTCRbeta rearrangementsDevelopmental stagesT-cell lineageTCR complexLociLineage cellsLineagesGenesDistinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.
Eynon E, Livák F, Kuida K, Schatz D, Flavell R. Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. The Journal Of Immunology 1999, 162: 1448-59. PMID: 9973401, DOI: 10.4049/jimmunol.162.3.1448.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell DivisionCell SurvivalGene ExpressionGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGenes, bcl-2Janus Kinase 3MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicProtein-Tyrosine KinasesReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSignal TransductionT-Lymphocyte SubsetsConceptsJak3-/- miceGammadelta T cell lineagesThymocyte developmentTransduction of signalsTCRbeta chain gene rearrangementLineage differentiationGammadelta lineageCell lineagesGene resultsKinase 3Developmental blockadeEarly thymocyte differentiationCytokine receptorsGamma locusT-cell lineageTargeted deletionBcl-2 expressionThymocyte differentiationTCRbeta transgeneIL-2 familyLineagesDifferentiationImmature thymocytesTransgeneSevere reduction