Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking
Turka L, Schatz D, Oettinger M, Chun J, Gorka C, Lee K, McCormack W, Thompson C. Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking. Science 1991, 253: 778-781. PMID: 1831564, DOI: 10.1126/science.1831564.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD3 ComplexCell DifferentiationCell SurvivalDNA NucleotidyltransferasesDNA-Binding ProteinsGene ExpressionGene Rearrangement, T-LymphocyteHomeodomain ProteinsHumansMiceNuclear ProteinsNucleic Acid HybridizationProteinsReceptor AggregationReceptors, Antigen, T-CellReceptors, Interleukin-2RNA, MessengerThymus GlandT-Lymphocyte SubsetsVDJ RecombinasesConceptsMajor histocompatibility complexCortical thymocytesSelf-major histocompatibility complexT cell receptor expressionHLA class IRAG-2Cell receptor expressionTCR complexRAG expressionT cell developmentT cell surfaceThymic subpopulationsCD4-CD8Intact thymusReceptor expressionThymic maturationRAG-1RAG-2 expressionThymocyte TCRThymocyte maturationHistocompatibility complexClass IReceptor crossThymocyte expressionBlot analysis