A Basic Motif in the N-Terminal Region of RAG1 Enhances V(D)J Recombination Activity
McMahan C, Difilippantonio M, Rao N, Spanopoulou E, Schatz D. A Basic Motif in the N-Terminal Region of RAG1 Enhances V(D)J Recombination Activity. Molecular And Cellular Biology 1997, 17: 4544-4552. PMID: 9234712, PMCID: PMC232308, DOI: 10.1128/mcb.17.8.4544.Peer-Reviewed Original ResearchConceptsBasic amino acid motifN-terminal regionSite-specific DNA recognitionRecombination activityCell-specific componentsComponent gene segmentsExtrachromosomal recombination substratesAmino acid motifsAmino acids 216Site-specific recombination reactionAntigen receptor genesEvolutionary conservationNuclear transportRAG2 proteinsRAG1 proteinRecombination functionsRecombination substratesDeletion analysisDNA recognitionEnzymatic machineryAcid motifFurther mutagenesisSRP-1N-terminusRAG1