1995
In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision
Livak F, Petrie H, Crisps I, Schatz D. In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision. Immunity 1995, 2: 617-627. PMID: 7796295, DOI: 10.1016/1074-7613(95)90006-3.Peer-Reviewed Original ResearchConceptsT cell lineage decisionsCell lineage decisionsLineage decisionsRandom gene rearrangementsSouthern blot analysisT cell receptor complexCell receptor complexGene rearrangementsDelta locusLocus sequenceGamma delta lineageReceptor complexT cell receptorBlot analysisDistinct precursorsCommon precursorCell receptorCritical roleDelta rearrangementsDelta lineageRearrangementΔ gene rearrangementAlpha betaT cellsGamma delta T-cell receptor
1991
Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking
Turka L, Schatz D, Oettinger M, Chun J, Gorka C, Lee K, McCormack W, Thompson C. Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking. Science 1991, 253: 778-781. PMID: 1831564, DOI: 10.1126/science.1831564.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD3 ComplexCell DifferentiationCell SurvivalDNA NucleotidyltransferasesDNA-Binding ProteinsGene ExpressionGene Rearrangement, T-LymphocyteHomeodomain ProteinsHumansMiceNuclear ProteinsNucleic Acid HybridizationProteinsReceptor AggregationReceptors, Antigen, T-CellReceptors, Interleukin-2RNA, MessengerThymus GlandT-Lymphocyte SubsetsVDJ RecombinasesConceptsMajor histocompatibility complexCortical thymocytesSelf-major histocompatibility complexT cell receptor expressionHLA class IRAG-2Cell receptor expressionTCR complexRAG expressionT cell developmentT cell surfaceThymic subpopulationsCD4-CD8Intact thymusReceptor expressionThymic maturationRAG-1RAG-2 expressionThymocyte TCRThymocyte maturationHistocompatibility complexClass IReceptor crossThymocyte expressionBlot analysisThe recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system
Chun J, Schatz D, Oettinger M, Jaenisch R, Baltimore D. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell 1991, 64: 189-200. PMID: 1986864, DOI: 10.1016/0092-8674(91)90220-s.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBase SequenceBrainCell DivisionCell LineChromosome MappingCytarabineGenesMiceMice, Inbred BALB CMolecular Sequence DataNeuronsNucleic Acid HybridizationOligonucleotide ProbesOrgan SpecificityPolymerase Chain ReactionRecombination, GeneticRNA ProbesTeratomaTranscription, GeneticTretinoinConceptsCentral nervous systemRAG-1 transcriptsMurine central nervous systemNervous systemHigh neuronal cell densityRAG-2 transcriptsSite-specific recombination machineryNeuronal cell densityNorthern blot analysisRecombination machineryGenome sitesPolymerase chain reactionRAG-2Postnatal brainPostnatal neuronsDetrimental alterationsRAG-1TranscriptsSitu hybridizationBlot analysisChain reactionNeuronsCell densityRecombination