1999
Regulation of Phospholipase Cγ in the Mesolimbic Dopamine System by Chronic Morphine Administration
Wolf D, Numan S, Nestler E, Russell D. Regulation of Phospholipase Cγ in the Mesolimbic Dopamine System by Chronic Morphine Administration. Journal Of Neurochemistry 1999, 73: 1520-1528. PMID: 10501197, PMCID: PMC1993239, DOI: 10.1046/j.1471-4159.1999.0731520.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDopamineDrug ImplantsGene Expression RegulationGene Expression Regulation, EnzymologicInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsIsoenzymesLimbic SystemMaleMorphineNeuronsOrgan SpecificityPhosphatidylinositol 3-KinasesPhospholipase C gammaPhosphoproteinsRatsRats, Sprague-DawleyRNA, MessengerTegmentum MesencephaliTranscription, GeneticType C PhospholipasesConceptsRas-ERK pathwayInsulin receptor substrateVentral tegmental areaNeurotrophic signaling pathwaysMesolimbic dopamine systemPhospholipase Cgamma1Receptor substratePhospholipase CγSignaling pathwaysPathway proteinsDopamine systemProteinPLCgamma1MRNA levelsChronic morphine exposureChronic morphine administrationRegulationPathwayAppreciable levelsMRNA expressionMorphine exposureMorphine administrationDopaminergic neuronsNeurotrophic factorTegmental area
1995
Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system
Berhow M, Russell D, Terwilliger R, Beitner-Johnson D, Self D, Lindsay R, Nestler E. Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience 1995, 68: 969-979. PMID: 8545003, DOI: 10.1016/0306-4522(95)00207-y.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdenylyl CyclasesAnimalsAutoradiographyCocaineCyclic AMP-Dependent Protein KinasesDopamineGlial Fibrillary Acidic ProteinInjectionsLimbic SystemMaleMorphineNarcotic AntagonistsNarcoticsNerve Growth FactorsNeurofilament ProteinsNucleus AccumbensRatsRats, Sprague-DawleyTyrosine 3-MonooxygenaseVentral Tegmental AreaConceptsVentral tegmental areaIntra-ventral tegmental area infusionBrain-derived neurotrophic factorGlial fibrillary acidic proteinTyrosine hydroxylase levelsNeurotrophic factorFactor infusionFibrillary acidic proteinTegmental areaMorphine treatmentNerve growth factorAdenylyl cyclase activityNucleus accumbensTyrosine hydroxylaseChronic morphineNeurotrophin-4Cocaine treatmentCocaine exposureHydroxylase levelsGlial fibrillary acidic protein levelsAcidic proteinCyclase activityGrowth factorChronic morphine treatmentChronic cocaine treatment