2003
Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors
Bolaños C, Perrotti L, Edwards S, Eisch A, Barrot M, Olson V, Russell D, Neve R, Nestler E. Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors. Journal Of Neuroscience 2003, 23: 7569-7576. PMID: 12930795, PMCID: PMC6740761, DOI: 10.1523/jneurosci.23-20-07569.2003.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDrugs of abuseAnxiety-like behaviorOverexpression of PLCgamma1Nociceptive stimuliTegmental areaAversive stimuliCaudal ventral tegmental areaDrug-induced elevationMood-related behaviorsMorphine place preferenceMorphine-paired compartmentDistinct topographical regionsViral-mediated gene transferEmotional stimuliNeurotrophic factorNeural substratesNatural rewardsPlace preference
1999
Regulation of Phospholipase Cγ in the Mesolimbic Dopamine System by Chronic Morphine Administration
Wolf D, Numan S, Nestler E, Russell D. Regulation of Phospholipase Cγ in the Mesolimbic Dopamine System by Chronic Morphine Administration. Journal Of Neurochemistry 1999, 73: 1520-1528. PMID: 10501197, PMCID: PMC1993239, DOI: 10.1046/j.1471-4159.1999.0731520.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDopamineDrug ImplantsGene Expression RegulationGene Expression Regulation, EnzymologicInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsIsoenzymesLimbic SystemMaleMorphineNeuronsOrgan SpecificityPhosphatidylinositol 3-KinasesPhospholipase C gammaPhosphoproteinsRatsRats, Sprague-DawleyRNA, MessengerTegmentum MesencephaliTranscription, GeneticType C PhospholipasesConceptsRas-ERK pathwayInsulin receptor substrateVentral tegmental areaNeurotrophic signaling pathwaysMesolimbic dopamine systemPhospholipase Cgamma1Receptor substratePhospholipase CγSignaling pathwaysPathway proteinsDopamine systemProteinPLCgamma1MRNA levelsChronic morphine exposureChronic morphine administrationRegulationPathwayAppreciable levelsMRNA expressionMorphine exposureMorphine administrationDopaminergic neuronsNeurotrophic factorTegmental area