Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.
Widnell K, Self D, Lane S, Russell D, Vaidya V, Miserendino M, Rubin C, Duman R, Nestler E. Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 306-15. PMID: 8558448.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesDown-RegulationGTP-Binding ProteinsMaleMolecular Sequence DataMorphineNucleus AccumbensOligonucleotides, AntisenseProtein Sorting SignalsRatsRats, Sprague-DawleyRNA, MessengerSensitivity and SpecificitySignal TransductionConceptsCAMP response element-binding proteinEffects of morphineNucleus accumbensBrain regionsCREB levelsChronic opiate administrationCAMP pathwayTranscription factor cAMP response element-binding proteinResponse element-binding proteinProperties of opiatesMorphine administrationAnti-sense oligonucleotide strategyMorphine actionOpiate administrationSustained decreaseLong-term effectsElement-binding proteinNervous systemCREB expressionOpiate addictionCREB immunoreactivityDetectable toxicityVivo evidenceMorphineAccumbens