1996
Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.
Widnell K, Self D, Lane S, Russell D, Vaidya V, Miserendino M, Rubin C, Duman R, Nestler E. Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 306-15. PMID: 8558448.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesDown-RegulationGTP-Binding ProteinsMaleMolecular Sequence DataMorphineNucleus AccumbensOligonucleotides, AntisenseProtein Sorting SignalsRatsRats, Sprague-DawleyRNA, MessengerSensitivity and SpecificitySignal TransductionConceptsCAMP response element-binding proteinEffects of morphineNucleus accumbensBrain regionsCREB levelsChronic opiate administrationCAMP pathwayTranscription factor cAMP response element-binding proteinResponse element-binding proteinProperties of opiatesMorphine administrationAnti-sense oligonucleotide strategyMorphine actionOpiate administrationSustained decreaseLong-term effectsElement-binding proteinNervous systemCREB expressionOpiate addictionCREB immunoreactivityDetectable toxicityVivo evidenceMorphineAccumbens
1994
Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro.
Widnell K, Russell D, Nestler E. Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 10947-10951. PMID: 7971989, PMCID: PMC45143, DOI: 10.1073/pnas.91.23.10947.Peer-Reviewed Original ResearchConceptsLocus coeruleusCREB expressionCREB immunoreactivityCell linesChronic morphine administrationLocus coeruleus neuronsCRE-binding activityResponse element-binding proteinCAMP pathwayCREB mRNA levelsCAMP response element-binding proteinMorphine administrationChronic morphineCoeruleus neuronsBrain regionsCRE bindingOpiate addictionElement-binding proteinPC12 pheochromocytoma cellsCAMP response elementMRNA levelsPheochromocytoma cellsCoeruleusImmunoreactivityCREB mRNA