Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors
Bolaños C, Perrotti L, Edwards S, Eisch A, Barrot M, Olson V, Russell D, Neve R, Nestler E. Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors. Journal Of Neuroscience 2003, 23: 7569-7576. PMID: 12930795, PMCID: PMC6740761, DOI: 10.1523/jneurosci.23-20-07569.2003.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDrugs of abuseAnxiety-like behaviorOverexpression of PLCgamma1Nociceptive stimuliTegmental areaAversive stimuliCaudal ventral tegmental areaDrug-induced elevationMood-related behaviorsMorphine place preferenceMorphine-paired compartmentDistinct topographical regionsViral-mediated gene transferEmotional stimuliNeurotrophic factorNeural substratesNatural rewardsPlace preference