2006
Protecting Motor Neurons from Toxic Insult by Antagonism of Adenosine A2a and Trk Receptors
Mojsilovic-Petrovic J, Jeong GB, Crocker A, Arneja A, David S, Russell D, Kalb RG. Protecting Motor Neurons from Toxic Insult by Antagonism of Adenosine A2a and Trk Receptors. Journal Of Neuroscience 2006, 26: 9250-9263. PMID: 16957081, PMCID: PMC6674510, DOI: 10.1523/jneurosci.1856-06.2006.Peer-Reviewed Original ResearchConceptsMotor neuronsAmyotrophic lateral sclerosisAdenosine A2A receptorsA2A receptorsBrain-derived neurotrophic factor (BDNF) activationReceptor tyrosine kinase BAbility of BDNFTyrosine kinase BMotor neuron diseaseSrc family kinasesAbnormal axonal transportFamilial motor neuron diseaseDirect kinase inhibitionExcitotoxic insultALS patientsNeuron diseaseAdenosine A2ALateral sclerosisTrk receptorsToxic insultsAxonal transportNeuronsInsultTransactivation pathwayFactor activation
2000
Brain‐Derived Neurotrophic Factor Induces Excitotoxic Sensitivity in Cultured Embryonic Rat Spinal Motor Neurons Through Activation of the Phosphatidylinositol 3‐Kinase Pathway
Fryer H, Wolf D, Knox R, Strittmatter S, Pennica D, O'Leary R, Russell D, Kalb R. Brain‐Derived Neurotrophic Factor Induces Excitotoxic Sensitivity in Cultured Embryonic Rat Spinal Motor Neurons Through Activation of the Phosphatidylinositol 3‐Kinase Pathway. Journal Of Neurochemistry 2000, 74: 582-595. PMID: 10646509, DOI: 10.1046/j.1471-4159.2000.740582.x.Peer-Reviewed Original ResearchConceptsHerpes simplex virusBrain-derived neurotrophic factorNeurotrophic factorMotor neuronsGlial-derived neurotrophic factorRat spinal motor neuronsEffects of BDNFRat motor neuronsSpinal motor neuronsActivation of TrkBPI3K pathwayExcitotoxic deathNeurotrophin-3Receptor p75NTRBDNFSimplex virusIntracellular Ca2Cardiotrophin-1NeuronsReceptor-mediated cell deathK pathwayPI3KDominant negative p85 subunitTrkBCell death