Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin
Provost E, McCabe A, Stern J, Lizardi I, D'Aquila TG, Rimm DL. Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin. Oncogene 2004, 24: 2667-2676. PMID: 15829978, DOI: 10.1038/sj.onc.1208346.Peer-Reviewed Original ResearchConceptsThreonine residuesΒ-cateninStable MDCK cell linesCell linesCadherin-mediated adhesionMutant β-cateninMutant cell linesExon 3Stable cell linesDestruction motifKinase substrateTranscriptional activationUbiquitination statusMultifunctional proteinMDCK cell lineCellular transformationTarget genesKey serineFunctional implicationsTransforming propertiesMutationsResiduesMotifG34Ubiquitination