2016
Early and multiple origins of metastatic lineages within primary tumors
Zhao ZM, Zhao B, Bai Y, Iamarino A, Gaffney SG, Schlessinger J, Lifton RP, Rimm DL, Townsend JP. Early and multiple origins of metastatic lineages within primary tumors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 2140-2145. PMID: 26858460, PMCID: PMC4776530, DOI: 10.1073/pnas.1525677113.Peer-Reviewed Original ResearchConceptsMetastatic lineagesGenetic changesEarly genetic divergenceMolecular evolutionary modelsSingle genetic changeDivergent lineagesTumor phylogeneticsDivergence timesAncestral stateGenetic divergenceCancer lineagesPhylogenetic analysisEvolutionary processesLineagesCancer evolutionMultiple originsDriver genesCancer biologyCancer progressionSomatic mutationsTumor developmentEvolutionary modelsDriver mutationsChronogramMutations
2007
Utility of multispectral imaging for nuclear classification of routine clinical histopathology imagery
Boucheron LE, Bi Z, Harvey NR, Manjunath B, Rimm DL. Utility of multispectral imaging for nuclear classification of routine clinical histopathology imagery. BMC Molecular And Cell Biology 2007, 8: s8. PMID: 17634098, PMCID: PMC1924513, DOI: 10.1186/1471-2121-8-s1-s8.Peer-Reviewed Original Research