2021
An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy
Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.Peer-Reviewed Original ResearchConceptsMemorial Sloan-Kettering Cancer CenterCore biopsyPredictive valueDiagnostic accuracyProstate core needle biopsiesCore needle biopsySurgical pathology practiceNegative predictive valueProstate core biopsiesPositive predictive valueProstate cancer detectionStrong diagnostic accuracyPoor quality scansCancer detectionCancer CenterProstate biopsyLeading causeNeedle biopsyTransrectal approachProstate cancerProstatic adenocarcinomaProstate carcinomaBiopsyPathology practiceProstate
2019
Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the BRAF, EGFR, and KRAS Genes: A Study of the College of American Pathologists Molecular Oncology Committee
Moncur JT, Bartley AN, Bridge JA, Kamel-Reid S, Lazar AJ, Lindeman NI, Long TA, Merker JD, Rai AJ, Rimm DL, Rothberg PG, Vasalos P, Kim AS. Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the BRAF, EGFR, and KRAS Genes: A Study of the College of American Pathologists Molecular Oncology Committee. Archives Of Pathology & Laboratory Medicine 2019, 143: 1203-1211. PMID: 30969158, DOI: 10.5858/arpa.2018-0396-cp.Peer-Reviewed Original Research
2018
Macrodissection prior to closed system RT-qPCR is not necessary for estrogen receptor and HER2 concordance with IHC/FISH in breast cancer
Gupta S, Mani NR, Carvajal-Hausdorf DE, Bossuyt V, Ho K, Weidler J, Wong W, Rhees B, Bates M, Rimm DL. Macrodissection prior to closed system RT-qPCR is not necessary for estrogen receptor and HER2 concordance with IHC/FISH in breast cancer. Laboratory Investigation 2018, 98: 1076-1083. PMID: 29858579, PMCID: PMC6119113, DOI: 10.1038/s41374-018-0064-1.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryIn Situ Hybridization, FluorescenceParaffin EmbeddingPathology, ClinicalReal-Time Polymerase Chain ReactionReceptor, ErbB-2Receptors, EstrogenReproducibility of ResultsSensitivity and SpecificityTissue FixationConceptsIHC/FISHDCIS cohortRT-qPCRMRNA transcript levelsDuctal carcinoma casesFine needle aspiratesMRNA expression levelsHER2 concordanceER positivityDuctal carcinomaHER2 expressionGeneXpert systemCarcinoma casesInvasive tumorsNeedle biopsyBreast cancerEstrogen receptorClinical ImmunohistochemistryBiopsy areaTumor tissueMRNA expressionTumor areaCohortMRNA levelsMRNA markers
2015
Measurement of Domain-Specific HER2 (ERBB2) Expression May Classify Benefit From Trastuzumab in Breast Cancer
Carvajal-Hausdorf DE, Schalper KA, Pusztai L, Psyrri A, Kalogeras KT, Kotoula V, Fountzilas G, Rimm DL. Measurement of Domain-Specific HER2 (ERBB2) Expression May Classify Benefit From Trastuzumab in Breast Cancer. Journal Of The National Cancer Institute 2015, 107: djv136. PMID: 25991002, PMCID: PMC4554192, DOI: 10.1093/jnci/djv136.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntibodies, Monoclonal, HumanizedAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorBreast NeoplasmsChemotherapy, AdjuvantClinical Trials as TopicDisease-Free SurvivalExtracellular SpaceFemaleFluorescent Antibody TechniqueGene Expression Regulation, NeoplasticHumansIntracellular SpaceKaplan-Meier EstimateMiddle AgedPredictive Value of TestsPrognosisReceptor, ErbB-2Sensitivity and SpecificityTissue Array AnalysisTrastuzumabTreatment OutcomeConceptsHuman epidermal growth factor receptor 2ECD expressionICD statusLonger DFSQuantitative immunofluorescenceTrastuzumab therapyPrognostic valueBreast cancerTissue microarrayEpidermal growth factor receptor 2Adjuvant trastuzumab therapyDisease-free survival analysisTrastuzumab-treated patientsGrowth factor receptor 2High positive predictive valueHER2-positive tumorsKaplan-Meier estimatesFactor receptor 2ERBB2 gene amplificationHER2 protein expressionPositive predictive valueExtracellular domainAdjuvant chemotherapyHER2-ICDBetter DFS
2014
Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time
Vassilakopoulou M, Parisi F, Siddiqui S, England AM, Zarella ER, Anagnostou V, Kluger Y, Hicks DG, Rimm DL, Neumeister VM. Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time. Laboratory Investigation 2014, 95: 334-341. PMID: 25418580, DOI: 10.1038/labinvest.2014.139.Peer-Reviewed Original ResearchConceptsCold ischemic timeIschemic timeFormalin fixationCompanion diagnostic testingCancer patientsBreast cancerTissue microarrayPhospho-HSP27Breast tumorsDiagnostic testingQuantitative immunofluorescenceAQUA technologyPreanalytical variablesGene expression profilingLoss of antigenicityTissue samplesReproducible assessmentProtein levelsConfidence intervalsSpecimen collectionExpression levelsPhosphorylation levelsAntigenicityRoutine usageResearch settings
2010
Antibody validation
Bordeaux J, Welsh A, Agarwal S, Killiam E, Baquero M, Hanna J, Anagnostou V, Rimm D. Antibody validation. BioTechniques 2010, 48: 197-209. PMID: 20359301, PMCID: PMC3891910, DOI: 10.2144/000113382.Peer-Reviewed Original Research
2009
C-Raf Is Associated with Disease Progression and Cell Proliferation in a Subset of Melanomas
Jilaveanu LB, Zito CR, Aziz SA, Conrad PJ, Schmitz JC, Sznol M, Camp RL, Rimm DL, Kluger HM. C-Raf Is Associated with Disease Progression and Cell Proliferation in a Subset of Melanomas. Clinical Cancer Research 2009, 15: 5704-5713. PMID: 19737955, PMCID: PMC2763114, DOI: 10.1158/1078-0432.ccr-09-0198.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBenzenesulfonatesCell Line, TumorCell ProliferationCell SurvivalCohort StudiesDisease ProgressionFemaleGene SilencingHumansIndolesMaleMelanomaMiddle AgedNevusNiacinamidePhenolsPhenylurea CompoundsProtein Kinase InhibitorsProto-Oncogene Proteins c-rafPyridinesRNA, Small InterferingSensitivity and SpecificitySkin NeoplasmsSorafenibYoung AdultConceptsExtracellular signal-regulated kinaseC-RafC-Raf expressionSubset of melanomasPhospho-c-RafSignal-regulated kinaseCell linesProtein kinase inhibitionMitogen-activated protein kinase inhibitionDecreased viabilityDecreased Bcl-2 expressionProtein kinaseCell signalingBcl-2 inhibitionRaf kinaseB-RafMelanoma cell linesPhospho-MEKSpecific siRNAsSitu protein expressionGW5074Major isoformsKinasePhospho-ERKBcl-2 expression
2008
Comparison of quantitative immunofluorescence with conventional methods for HER2/neu testing with respect to response to trastuzumab therapy in metastatic breast cancer.
Giltnane JM, Molinaro A, Cheng H, Robinson A, Turbin D, Gelmon K, Huntsman D, Rimm DL. Comparison of quantitative immunofluorescence with conventional methods for HER2/neu testing with respect to response to trastuzumab therapy in metastatic breast cancer. Archives Of Pathology & Laboratory Medicine 2008, 132: 1635-47. PMID: 18834223, DOI: 10.5858/2008-132-1635-coqiwc.Peer-Reviewed Original ResearchAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBreast NeoplasmsCell LineCricetinaeFemaleHumansImmunohistochemistryIn Situ Hybridization, FluorescenceLogistic ModelsMiddle AgedPredictive Value of TestsReceptor, ErbB-2Retrospective StudiesSensitivity and SpecificityTissue Array AnalysisTrastuzumabTreatment Outcome
2007
Fine‐needle aspiration of follicular adenoma versus parathyroid adenoma
Mansoor I, Zalles C, Zahid F, Gossage K, Levenson RM, Rimm DL. Fine‐needle aspiration of follicular adenoma versus parathyroid adenoma. Cancer 2007, 114: 22-26. PMID: 18085636, DOI: 10.1002/cncr.23252.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaDiagnosis, DifferentialDiagnostic ImagingHumansParathyroid NeoplasmsPredictive Value of TestsSensitivity and SpecificitySpectrum AnalysisThyroid NeoplasmsConceptsArtificial intelligence systemsSpatial-spectral featuresSpectral image informationMultispectral image analysisIntelligence systemsImage informationAlgorithmic solutionTraining setImage stacksImaging solutionImage analysisTest casesHuman eyeImagesClassifierSoftwareToolPlatformSolutionTechnologyInformationSetQuantitative Measurement of Epidermal Growth Factor Receptor Is a Negative Predictive Factor for Tamoxifen Response in Hormone Receptor–Positive Premenopausal Breast Cancer
Giltnane JM, Rydén L, Cregger M, Bendahl PO, Jirström K, Rimm DL. Quantitative Measurement of Epidermal Growth Factor Receptor Is a Negative Predictive Factor for Tamoxifen Response in Hormone Receptor–Positive Premenopausal Breast Cancer. Journal Of Clinical Oncology 2007, 25: 3007-3014. PMID: 17634479, DOI: 10.1200/jco.2006.08.9938.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkersBiopsy, NeedleBreast NeoplasmsDrug Resistance, NeoplasmErbB ReceptorsEstrogen AntagonistsFemaleHumansImmunohistochemistryMiddle AgedMultivariate AnalysisPredictive Value of TestsPremenopauseProbabilityProportional Hazards ModelsReceptors, EstrogenRisk AssessmentSensitivity and SpecificitySurvival AnalysisTamoxifenConceptsEpidermal growth factor receptorER-positive patientsEGFR expressionBreast cancerEstrogen receptorTamoxifen-treated patientsEarly breast cancerRecurrence-free survivalRandomized clinical trialsLow EGFR expressionSignificant beneficial effectAdjuvant tamoxifenGrowth factor receptorEndocrine therapyTamoxifen responseTamoxifen treatmentClinical trialsSitu protein expressionUntreated groupTissue microarrayPatientsBeneficial effectsProtein expressionFactor receptorTreatment effectsUtility of multispectral imaging for nuclear classification of routine clinical histopathology imagery
Boucheron LE, Bi Z, Harvey NR, Manjunath B, Rimm DL. Utility of multispectral imaging for nuclear classification of routine clinical histopathology imagery. BMC Molecular And Cell Biology 2007, 8: s8. PMID: 17634098, PMCID: PMC1924513, DOI: 10.1186/1471-2121-8-s1-s8.Peer-Reviewed Original ResearchBimodal Population or Pathologist Artifact?
Rimm DL, Giltnane JM, Moeder C, Harigopal M, Chung GG, Camp RL, Burtness B. Bimodal Population or Pathologist Artifact? Journal Of Clinical Oncology 2007, 25: 2487-2488. PMID: 17557963, DOI: 10.1200/jco.2006.07.7537.Peer-Reviewed Original ResearchQuantitative analysis of estrogen receptor heterogeneity in breast cancer
Chung GG, Zerkowski MP, Ghosh S, Camp RL, Rimm DL. Quantitative analysis of estrogen receptor heterogeneity in breast cancer. Laboratory Investigation 2007, 87: 662-669. PMID: 17334408, DOI: 10.1038/labinvest.3700543.Peer-Reviewed Original ResearchAdenocarcinomaAutomationBiomarkers, TumorBreast NeoplasmsFemaleHumansImage Processing, Computer-AssistedImmunohistochemistryLinear ModelsNeoplasm ProteinsObserver VariationParaffin EmbeddingPrognosisProtein Array AnalysisReceptors, EstrogenReproducibility of ResultsResearch DesignRetrospective StudiesSensitivity and Specificity
2006
What brown cannot do for you
Rimm DL. What brown cannot do for you. Nature Biotechnology 2006, 24: 914-916. PMID: 16900128, DOI: 10.1038/nbt0806-914.Peer-Reviewed Original Research
2005
Fine Needle Aspiration Is a Feasible and Accurate Technique in the Diagnosis of Lymphoma
Austin R, Birdsong G, Sidawy M, Kaminsky D, Benstein B, Cibas E, Mody D, Guidos B, Moriarty A, Rimm D, Ehya H, Facik M, Howell L, Gill G, Kurtycz D, Powers C, Young N. Fine Needle Aspiration Is a Feasible and Accurate Technique in the Diagnosis of Lymphoma. Journal Of Clinical Oncology 2005, 23: 9029-9030. PMID: 16339755, DOI: 10.1200/jco.2005.01.5248.Peer-Reviewed Original Research
2004
Diagnostic classification of urothelial cells in urine cytology specimens using exclusively spectral information
Jaganath R, Angeletti C, Levenson R, Rimm DL. Diagnostic classification of urothelial cells in urine cytology specimens using exclusively spectral information. Cancer 2004, 102: 186-191. PMID: 15211478, DOI: 10.1002/cncr.20302.Peer-Reviewed Original ResearchThe histologic subtype of ovarian tumors affects the detection rate by pelvic washings
Fadare O, Mariappan MR, Wang, Hileeto D, Mcalpine J, Rimm DL. The histologic subtype of ovarian tumors affects the detection rate by pelvic washings. Cancer 2004, 102: 150-156. PMID: 15211473, DOI: 10.1002/cncr.20239.Peer-Reviewed Original ResearchConceptsHistologic subtypeOvarian tumorsPeritoneal involvementPelvic washingsPelvic washesBorderline tumorsAdnexal massesCommon histologic subtypeClear cell carcinomaOvarian surface involvementTumor detection rateDetection rateFisher's exact testCurrent studyTumoral involvementHistologic concordanceSerous carcinomaCell carcinomaUndifferentiated carcinomaSurface involvementPeritoneal surfaceConsecutive groupClear cellsIndividual histologic subtypesMost centersQuantitative Determination of Expression of the Prostate Cancer Protein α-Methylacyl-CoA Racemase Using Automated Quantitative Analysis (AQUA) A Novel Paradigm for Automated and Continuous Biomarker Measurements
Rubin MA, Zerkowski MP, Camp RL, Kuefer R, Hofer MD, Chinnaiyan AM, Rimm DL. Quantitative Determination of Expression of the Prostate Cancer Protein α-Methylacyl-CoA Racemase Using Automated Quantitative Analysis (AQUA) A Novel Paradigm for Automated and Continuous Biomarker Measurements. American Journal Of Pathology 2004, 164: 831-840. PMID: 14982837, PMCID: PMC1613273, DOI: 10.1016/s0002-9440(10)63171-9.Peer-Reviewed Original ResearchConceptsProstate cancerProstate tissue samplesAMACR protein expressionTissue samplesProtein expressionProstate tissueZ-scoreAcinar prostate cancerLow AMACR expressionΑ-Methylacyl-CoA racemaseTissue microarray samplesTissue microarray slidesBenign prostate tissueProgression tissue microarrayMetastatic tumor samplesTissue-based markersMost tissue samplesProstate tissue biomarkersProstate cancer biomarkersBenign prostate tissue samplesImmunohistochemical evaluationSeparation of tumorAMACR expressionTissue biomarkersTissue microarray
2000
E‐cadherin expression is a sensitive and specific method for detection of carcinoma cells in fluid specimens
Schofield K, D'Aquila T, Rimm D. E‐cadherin expression is a sensitive and specific method for detection of carcinoma cells in fluid specimens. Diagnostic Cytopathology 2000, 22: 263-267. PMID: 10790230, DOI: 10.1002/(sici)1097-0339(200005)22:5<263::aid-dc1>3.0.co;2-4.Peer-Reviewed Original ResearchThe utility of Ki-ras mutation analysis in the cytologic diagnosis of pancreatobiliary neoplasma.
Dillon DA, Johnson CC, Topazian MD, Tallini G, Rimm DL, Costa JC. The utility of Ki-ras mutation analysis in the cytologic diagnosis of pancreatobiliary neoplasma. The Cancer Journal 2000, 6: 294-301. PMID: 11079168.Peer-Reviewed Original ResearchConceptsFine needle aspiratesBile duct brushingsCytologic diagnosisPositive predictive valueCommon bile duct brushingsDuct brushingsPancreatobiliary carcinomaPredictive valueMutation patternsBiliary tract carcinomaPrevious retrospective studyAvailable clinical informationConsecutive clinical specimensDefinitive cytologic diagnosisPolymerase chain reaction/single-strand conformation polymorphism analysisRoutine cytologic diagnosisPositive cytologyRetrospective studySuspicious morphologyCytologic evaluationSuspicious cytologyPancreatobiliary tractClinical informationMorphologic diagnosisNeoplastic cells