Loss of Smad Signaling in Human Colorectal Cancer Is Associated with Advanced Disease and Poor Prognosis
Xie W, Rimm DL, Lin Y, Shih WJ, Reiss M. Loss of Smad Signaling in Human Colorectal Cancer Is Associated with Advanced Disease and Poor Prognosis. The Cancer Journal 2003, 9: 302-312. PMID: 12967141, DOI: 10.1097/00130404-200307000-00013.Peer-Reviewed Original ResearchConceptsColorectal cancerHuman colorectal cancerAdvanced diseasePoor prognosisHuman colorectal cancer specimensAdvanced stage diseasePresence of lymphLymph node metastasisColorectal cancer specimensShorter overall survivalClinical outcome informationOverall survivalNode metastasisClinical behaviorReceptor defectCancer specimensTissue microarrayAnimal studiesCancerSmad signalingOutcome informationPhosphorylated Smad2DiseaseSmad activationSmad2