DNA Hypermethylation of ESR1 and PGR in Breast Cancer: Pathologic and Epidemiologic Associations
Gaudet MM, Campan M, Figueroa JD, Yang XR, Lissowska J, Peplonska B, Brinton LA, Rimm DL, Laird PW, Garcia-Closas M, Sherman ME. DNA Hypermethylation of ESR1 and PGR in Breast Cancer: Pathologic and Epidemiologic Associations. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 3036-3043. PMID: 19861523, PMCID: PMC2783691, DOI: 10.1158/1055-9965.epi-09-0678.Peer-Reviewed Original ResearchConceptsBreast cancerPopulation-based case-control studyBreast cancer risk factorsPromoter CLevels of ERalphaPR-negative tumorsInvasive breast cancerCancer risk factorsCase-control studyPercentage of tumorsNegative breast cancerTumor tissue coresImproved risk predictionLower ERalphaTumor characteristicsPR expressionProgesterone receptorEpidemiologic associationRisk factorsInverse associationDNA hypermethylationPR levelsMost tumorsReceptor silencingTumors