Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose
Akirav EM, Baquero MT, Opare-Addo LW, Akirav M, Galvan E, Kushner JA, Rimm DL, Herold KC. Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose. Diabetes 2011, 60: 876-883. PMID: 21307078, PMCID: PMC3046848, DOI: 10.2337/db10-0793.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorIslet vascular densityNOD miceEndothelial cell densityGlucose toleranceEndothelial growth factorΒ-cellsVascular densityInsulin contentIslet vasculatureAnti-CD3 monoclonal antibodyEndothelial cellsGrowth factorDiabetic NOD micePrediabetic NOD miceAltered glucose toleranceImproved glucose toleranceEndothelial cell destructionType 1 diabetesAnti-CD3 mAbΒ-cell functionΒ-cell massHigh glucose levelsΒ-cell proliferationTransfer of supernatants