IFN-β alters neurotrophic factor expression in T cells isolated from multiple sclerosis patients - implication of novel neurotensin/NTSR1 pathway in neuroprotection.
Soltys J, Knight J, Scharf E, Pitt D, Mao-Draayer Y. IFN-β alters neurotrophic factor expression in T cells isolated from multiple sclerosis patients - implication of novel neurotensin/NTSR1 pathway in neuroprotection. American Journal Of Translational Research 2014, 6: 312-9. PMID: 24936223, PMCID: PMC4058312.Peer-Reviewed Original ResearchT cellsMultiple sclerosisNeurotrophin receptorActive demyelinating lesionsNeurotrophic factor expressionCytokine expression patternsHigh-affinity receptor 1Mechanism of actionDemyelinating lesionsMS pathogenesisRRMS patientsNeurotrophin productionNeuroprotective effectsNeurotrophin expressionNeuroprotective capabilitiesStem/progenitor cell survivalProgenitor cell survivalDisease pathogenesisReceptor 1Factor expressionIFNPotent inducerSpecific cell populationsCell populationsSclerosis