2024
Persistent bloodstream infection in children: examining the role for repeat blood cultures.
Puthawala C, Feinn R, Rivera-Viñas J, Lee H, Murray T, Peaper D. Persistent bloodstream infection in children: examining the role for repeat blood cultures. Journal Of Clinical Microbiology 2024, e0099824. PMID: 39365070, DOI: 10.1128/jcm.00998-24.Peer-Reviewed Original ResearchPositive blood culturesPersistent bloodstream infectionBlood culturesBloodstream infectionsCentral venous catheterPositive culturesVenous cathetersIndex blood cultureCross-sectional study of childrenRepeated blood culturesTime of blood drawElevated inflammatory markersAssociated with persistenceGt;48 hoursIndex cultureCross-sectional studyPersistent bacteremiaImmune dysfunctionPediatric patientsInflammatory markersDiagnostic stewardshipStudy of childrenPatient characteristicsClinical valueBlood drawPseudo-outbreak of Parengyodontium album related to contaminated saline used in specimen processing in the microbiology laboratory
Havill N, Colandrea N, Merwede J, Aniskiewicz M, Roberts S, Patel K, Martinello R, Peaper D. Pseudo-outbreak of Parengyodontium album related to contaminated saline used in specimen processing in the microbiology laboratory. American Journal Of Infection Control 2024, 52: 1099-1101. PMID: 38825239, DOI: 10.1016/j.ajic.2024.05.016.Peer-Reviewed Original ResearchPerformance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease
Landry M, Hassan S, Rottmann B, Pesak S, Ordazzo M, Skrzyniarz M, Deponte S, Peaper D. Performance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease. Journal Of Clinical Microbiology 2024, 62: e00139-24. PMID: 38597655, PMCID: PMC11077974, DOI: 10.1128/jcm.00139-24.Peer-Reviewed Original ResearchConceptsPositive percent agreementSerologic diagnosis of Lyme diseaseDiagnosis of Lyme diseaseEnzyme-linked immunoassayBorrelia speciesTwo-tier algorithmLyme diseaseTwo-tier testImmunoblottingLaboratory diagnosis of Lyme diseaseLIAISON chemiluminescent immunoassaysChemiluminescence immunoassayDetection of IgMScreening testConsensus reference standardSerological diagnosisLaboratory diagnosisDiaSorinIgM resultsIgM detectionAtypical pneumonia testing in transplant recipients
Feller F, Trubin P, Malinis M, Vogel J, Merwede J, Peaper D, Azar M. Atypical pneumonia testing in transplant recipients. Transplant Infectious Disease 2024, 26: e14256. PMID: 38430482, DOI: 10.1111/tid.14256.Peer-Reviewed Original ResearchHematopoietic stem cell transplantationTransplant recipientsPathogens of pneumoniaAtypical pneumoniaAugmented immunosuppressionAtypical pathogensTest positivity rateChimeric antigen receptor T cellsHematopoietic stem cell transplant recipientsDiagnosis of atypical pneumoniaPositive rateCases of mycoplasma infectionStem cell transplantationSolid organ transplantationRetrospective cohort studyMycoplasma infectionImmunocompromised patientsCell transplantationAnalysis of diagnostic testsDiagnostic yieldTransplant cohortPost-transplantationT cellsCohort studyRates of testingProceedings of the Clinical Microbiology Open 2022—assessing clinical laboratory and industry responses to COVID-19 pandemic testing capacity challenges (part 1)
Peaper D, Doern C, Sharp S, Council O. Proceedings of the Clinical Microbiology Open 2022—assessing clinical laboratory and industry responses to COVID-19 pandemic testing capacity challenges (part 1). Journal Of Clinical Microbiology 2024, 62: e00941-23. PMID: 38379142, PMCID: PMC10935657, DOI: 10.1128/jcm.00941-23.Peer-Reviewed Original ResearchClinical laboratoriesFood and Drug AdministrationCenters for Disease Control and PreventionClinical microbiologyDirectors of clinical laboratoriesPublic health laboratoriesDisease Control and PreventionControl and PreventionSARS-CoV-2 testingDrug AdministrationDiagnostic laboratoriesHealth laboratoriesPandemic responseInitial pandemic responseClinicNext pandemicStaffing challengesInformatics needs
2023
Retrospective evaluation of clinical decision support for within-laboratory optimization of SARS-CoV-2 NAAT workflow
Durant T, Peaper D. Retrospective evaluation of clinical decision support for within-laboratory optimization of SARS-CoV-2 NAAT workflow. Journal Of Clinical Microbiology 2023, 62: e00785-23. PMID: 38132702, PMCID: PMC10865785, DOI: 10.1128/jcm.00785-23.Peer-Reviewed Original ResearchData Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age
Merrill A, Durant T, Baron J, Klutts J, Obstfeld A, Peaper D, Stoffel M, Wheeler S, Zaydman M. Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age. Clinical Chemistry 2023, 69: 1333-1341. PMID: 37962514, DOI: 10.1093/clinchem/hvad183.Commentaries, Editorials and LettersEnhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
Moriyama M, Lucas C, Monteiro V, Initiative Y, Iwasaki A, Chen N, Breban M, Hahn A, Pham K, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Vogels C, Grubaugh N. Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2221652120. PMID: 37036977, PMCID: PMC10120007, DOI: 10.1073/pnas.2221652120.Peer-Reviewed Original ResearchConceptsMHC-I expressionBreakthrough infectionsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variantsMajor histocompatibility complex class I expressionCell-mediated immunityInfluenza virus infectionSARS-CoV-2 VOCsMHC-I upregulationClass I expressionSARS-CoV-2T cell recognitionVirus infectionMHC II expressionSpike proteinEnhanced inhibitionInfectionCell recognitionCommon mutationsReinfectionE proteinAntibodiesViral genesSubvariantsExpressionPROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data
Iscoe M, Loza A, Turbiville D, Campbell S, Peaper D, Balbuena-Merle R, Hauser R. PROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data. American Journal Of Clinical Pathology 2023, 160: 98-105. PMID: 37026746, DOI: 10.1093/ajcp/aqad024.Peer-Reviewed Original ResearchConceptsQuality improvement studyElectronic health recordsLaboratory valuesWeb-based clinical decision support toolClinical decision support toolElectronic health record dataHealth record dataImprovement studyResident trainingBlood smear interpretationClinical outcomesMorphologic findingsAcademic hospitalCorresponding reference rangesMedication informationReference rangeMicroscopy findingsCDS toolsIntervention effectsPathology practiceSmear interpretationHealth recordsRecord dataPathologistsPatientsChoice Architecture to Assist Clinicians with Appropriate COVID-19 Test Ordering
Sangal R, Venkatesh A, Cahill J, Pettker C, Peaper D. Choice Architecture to Assist Clinicians with Appropriate COVID-19 Test Ordering. The Journal Of Applied Laboratory Medicine 2023, 8: 98-105. PMID: 36610419, DOI: 10.1093/jalm/jfac104.Peer-Reviewed Original ResearchConceptsRSV testingSymptomatic visitsED visitsSARS-CoV-2 nucleic acid amplification testsCOVID-19Respiratory syncytial virus testingNucleic acid amplification testsElectronic health record ordersSystems-based interventionsSARS-CoV-2Symptomatic patientsPrimary outcomeInfluenza testingClinical guidelinesClinician educationClinician practiceVirus testingAmplification testsPatientsTest orderingInstitutional guidelinesClinical needHospital systemVisitsTesting patterns
2022
535. Evaluation of the BioFire Blood Culture Identification (BCID2) panel for transplant recipients with a bloodstream infection
Palacios C, Peaper D, Malinis M, Malinis M, Perreault S, Cohen E, Vogel J, Azar M. 535. Evaluation of the BioFire Blood Culture Identification (BCID2) panel for transplant recipients with a bloodstream infection. Open Forum Infectious Diseases 2022, 9: ofac492.588. PMCID: PMC9752191, DOI: 10.1093/ofid/ofac492.588.Peer-Reviewed Original ResearchBone marrow transplant recipientsTransplant recipientsBloodstream infectionsBlood culturesPositive blood culturesClinical trialsPrimary investigatorSolid organ recipientsMarrow transplant recipientsRetrospective chart reviewYear of transplantationAntimicrobial susceptibility resultsBlood Culture Identification PanelBSI eventsChart reviewOptimal therapyOrgan recipientsMean ageMultiplex PCR panelSame patientGeneral populationPolymicrobial culturesCandida sppPeripheral sitesRecipients195. Reducing Time to Optimal Antimicrobial Therapy (OAT) for Bloodstream Infections (BSI) due to Gram Positive Cocci (GPC) in Chains Using Rapid Diagnostics Paired with Antimicrobial Stewardship (ASP) Efforts
K J, McSweeney T, McManus D, Davis M, Merwede J, Peaper D, Topal J. 195. Reducing Time to Optimal Antimicrobial Therapy (OAT) for Bloodstream Infections (BSI) due to Gram Positive Cocci (GPC) in Chains Using Rapid Diagnostics Paired with Antimicrobial Stewardship (ASP) Efforts. Open Forum Infectious Diseases 2022, 9: ofac492.273. PMCID: PMC9752006, DOI: 10.1093/ofid/ofac492.273.Peer-Reviewed Original ResearchOptimal antimicrobial therapyLength of stayGram-positive cocciBloodstream infectionsASP recommendationsHigher Charlson comorbidity indexMedian LOSCharlson Comorbidity IndexPost-implementation cohortPre-implementation cohortPrimary study endpointRetrospective chart reviewRapid diagnosticsPositive Gram stainYears of ageAntimicrobial stewardship effortsASP interventionsComorbidity indexPrimary endpointBaseline demographicsChart reviewSecondary outcomesStudy endpointPolymicrobial infectionsAntimicrobial therapy
2021
Pyomyositis and Infectious Myositis: A Comprehensive, Single-Center Retrospective Study
Radcliffe C, Gisriel S, Niu YS, Peaper D, Delgado S, Grant M. Pyomyositis and Infectious Myositis: A Comprehensive, Single-Center Retrospective Study. Open Forum Infectious Diseases 2021, 8: ofab098. PMID: 33884279, PMCID: PMC8047863, DOI: 10.1093/ofid/ofab098.Peer-Reviewed Original ResearchInfectious myositisPercutaneous drainage proceduresRetrospective studyDrainage proceduresSingle-center retrospective studyThird of patientsTertiary care institutionTreatment success rateCases of pyomyositisSubjective feverMuscle painDiabetes mellitusAbscess formationCommon symptomsMedian lengthMean ageMental statusAntimicrobial therapyMost infectionsTreatment strategiesPyomyositisMyositisPathology specimensPatientsBacterial infections
2020
Nocardia veterana infections: case report and systematic review
Radcliffe C, Peaper D, Grant M. Nocardia veterana infections: case report and systematic review. New Microbes And New Infections 2020, 39: 100833. PMID: 33456780, PMCID: PMC7797559, DOI: 10.1016/j.nmni.2020.100833.Peer-Reviewed Case Reports and Technical NotesChronic cutaneous graftOral antibiotic therapySoft tissue abscessesHost diseaseCutaneous graftAntibiotic therapyPulmonary infectionCase reportDrainage proceduresEmpirical treatmentCondition warrantsSystematic reviewInfectionOpportunistic pathogenSystematic literature reviewFirst reportLiterature reviewReportAbscessRelapseReviewAzithromycinGraftTherapyNocardiaClinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients
Gaston DC, Malinis M, Osborn R, Peaper DR, Landry M, Juthani-Mehta M, Azar MM. Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients. American Journal Of Transplantation 2020, 21: 1304-1311. PMID: 33043603, PMCID: PMC7675520, DOI: 10.1111/ajt.16357.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsClinical implicationsCycle threshold valuesSOT patientsTransplant recipientsSymptom onsetYale New Haven Health SystemUpper respiratory tract samplesSARS-CoV-2 viral RNASARS-CoV-2 viral dynamicsAdult SOT recipientsRetrospective chart reviewRespiratory tract samplesSARS-CoV-2 cycle threshold valuesInfection prevention measuresCOVID-19 severityViral RNAHigher clinical acuityPrimary diagnostic testRT-PCR assaysSOT recipientsChart reviewViral loadAdmission severityCo-Culture of Acinetobacter calcoaceticus-baumannii complex and Staphylococcus saprophyticus Supports Simple Point Contamination Model in Recent Cases of Transfusion-Related Sepsis
Kerantzas C, Merwede J, Snyder E, Hendrickson J, Tormey C, Kazmierczak B, Peaper D. Co-Culture of Acinetobacter calcoaceticus-baumannii complex and Staphylococcus saprophyticus Supports Simple Point Contamination Model in Recent Cases of Transfusion-Related Sepsis. American Journal Of Clinical Pathology 2020, 154: s14-s14. DOI: 10.1093/ajcp/aqaa137.025.Peer-Reviewed Original ResearchOutcomes of Patients With Hospital-Acquired Influenza
Campbell M, James A, Fairweather I, Rivera-Vinas J, Kaslow R, Landry M, Peaper D, Martinello R. Outcomes of Patients With Hospital-Acquired Influenza. Infection Control And Hospital Epidemiology 2020, 41: s340-s340. DOI: 10.1017/ice.2020.951.Peer-Reviewed Original ResearchEscalation of careIntensive care unitCare unitLaboratory-proven influenzaOutcomes of patientsRetrospective cohort studyCommunity-based populationPediatric teaching hospitalLength of stayOnset of signsDiagnosis of pneumoniaMedical record informationDirect fluorescent antibodyNoninvasive ventilationChart reviewCohort studyInpatient morbidityMedian durationPatient demographicsAntiviral treatmentClinical courseRadiographic evidenceAntiviral administrationInfluenza infectionSupplemental oxygen
2019
Performance of the Procalcitonin Test in Diagnosing Pneumonia in Real-World Practice
Ayala-Lopez N, Ghaedi M, Peaper D, Harb R. Performance of the Procalcitonin Test in Diagnosing Pneumonia in Real-World Practice. American Journal Of Clinical Pathology 2019, 152: s36-s36. DOI: 10.1093/ajcp/aqz112.069.Peer-Reviewed Original ResearchChest X-rayDirect fluorescence antibodyWhite blood cellsHigher procalcitoninChest X-ray resultsReal-world clinical practicePositive chest X-rayRespiratory virus testingUtility of procalcitoninCulture-positive infectionsPCT resultsRespiratory tract culturesLower respiratory tractFinal clinical diagnosisPresence of pneumoniaCriterion 2Diagnosis of infectionProcalcitonin testElevated procalcitoninReal-world practiceRespiratory culturesMean agePatient populationAntibiotic stewardshipRespiratory tract
2018
Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections
Pruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin S, Aronson PL, Collaborative F, Nigrovic L, Browning W, Mitchell C, Peaper D, Feldman E. Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections. The Journal Of Pediatrics 2018, 204: 177-182.e1. PMID: 30297292, PMCID: PMC6309646, DOI: 10.1016/j.jpeds.2018.08.066.Peer-Reviewed Original ResearchConceptsInvasive bacterial infectionsFebrile young infantsAdverse outcomesBacterial meningitisYoung infantsIll appearanceFebrile infantsBacterial infectionsRetrospective cohort studyMedical record reviewLocal microbiology laboratoryMixed-effects logistic regressionElectronic medical record systemDays of ageIll appearingNeurologic sequelaeCohort studyMedical record systemClinical factorsMedication receiptMechanical ventilationRecord reviewClinical dataInclusion criteriaMeningitisEpidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency Departments
Woll C, Neuman MI, Pruitt CM, Wang ME, Shapiro ED, Shah SS, McCulloh RJ, Nigrovic LE, Desai S, DePorre AG, Leazer RC, Marble RD, Balamuth F, Feldman EA, Sartori LF, Browning WL, Aronson PL, Collaborative F, Alpern E, Hayes K, Lee B, Lumb C, Mitchell C, Peaper D, Rooholamini S, Shin S, Williams D. Epidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency Departments. The Journal Of Pediatrics 2018, 200: 210-217.e1. PMID: 29784512, PMCID: PMC6109608, DOI: 10.1016/j.jpeds.2018.04.033.Peer-Reviewed Original ResearchConceptsInvasive bacterial infectionsThird-generation cephalosporinsMicrobiology laboratory databaseEmergency departmentBacterial infectionsBacterial meningitisPediatric emergency departmentCombination of ampicillinAntimicrobial treatment regimenCross-sectional studyGroup B streptococciElectronic medical record systemEmpiric treatmentMedical record systemTreatment regimenChildren's HospitalMost infantsMedical recordsB streptococciCerebrospinal fluidCommon pathogensInfantsAntimicrobial susceptibilityDay oldsInfection