2023
Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria
Ivanics T, Claasen M, Samstein B, Emond J, Fox A, Pomfret E, Pomposelli J, Tabrizian P, Florman S, Mehta N, Roberts J, Emamaullee J, Genyk Y, Hernandez-Alejandro R, Tomiyama K, Sasaki K, Hashimoto K, Nagai S, Abouljoud M, Olthoff K, Hoteit M, Heimbach J, Taner T, Liapakis A, Mulligan D, Sapisochin G, Halazun K, Group O. Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria. Annals Of Surgery 2023, 279: 104-111. PMID: 37522174, DOI: 10.1097/sla.0000000000006049.Peer-Reviewed Original ResearchConceptsUniversity of California San FranciscoMilan criteriaDonor liver transplantationHepatocellular carcinomaOverall survivalLiver transplantationPosttransplantation survivalEvaluate long-term oncologic outcomesUniversity of California San Francisco criteriaLiving donor liver transplantationRecurrence-free survivalKaplan-Meier methodTransplant selection criteriaProportion of patientsAdult LDLT recipientsNorth American centersLong-term survivalLiver transplant waitlistCalifornia San FranciscoLDLT recipientsMulticenter cohortConsensus guidelinesTransplantationPatientsPosttransplantationLiving donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference
Jesse M, Jackson W, Liapakis A, Ganesh S, Humar A, Goldaracena N, Levitsky J, Mulligan D, Pomfret E, Ladner D, Roberts J, Mavis A, Thiessen C, Trotter J, Winder G, Griesemer A, Pillai A, Kumar V, Verna E, Rudow D, Han H, Group T. Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference. Clinical Transplantation 2023, 37: e14954. PMID: 36892182, DOI: 10.1111/ctr.14954.Peer-Reviewed Original ResearchMeSH KeywordsConsensusDonor SelectionHumansLiver TransplantationLiving DonorsTissue and Organ ProcurementUnited StatesConceptsDonor selectionConsensus conferenceDeceased donor organ shortageDonor liver transplantationLiver transplant candidatesDonor organ shortageLiver transplantationTransplant candidatesWaitlist mortalityExcellent outcomesLDLT candidatesOrgan shortageDonation outcomesLack of standardizationAmerican SocietyTransplantationDelphi approachBroad implementationMeeting reportOutcomesCandidate indicationsReportLDLTPatientsBroad uptake
2022
Clinical and Ethical Framework for Liver Retransplantation Using Living Donor Grafts: A Western Perspective
Batra RK, Mulligan DC. Clinical and Ethical Framework for Liver Retransplantation Using Living Donor Grafts: A Western Perspective. Liver Transplantation 2022, 28: 760-762. PMID: 34931433, DOI: 10.1002/lt.26395.Peer-Reviewed Original Research
2016
The Long‐Term Follow‐up and Support for Living Organ Donors: A Center‐Based Initiative Founded on Developing a Community of Living Donors
Kulkarni S, Thiessen C, Formica RN, Schilsky M, Mulligan D, D'Aquila R. The Long‐Term Follow‐up and Support for Living Organ Donors: A Center‐Based Initiative Founded on Developing a Community of Living Donors. American Journal Of Transplantation 2016, 16: 3385-3391. PMID: 27500361, DOI: 10.1111/ajt.14005.Peer-Reviewed Original Research
2014
Magnetic resonance elastography can discriminate normal vs. abnormal liver biopsy in candidates for live liver donation
Gallegos-Orozco JF, Silva AC, Batheja MJ, Chang YH, Hansen KL, Lam-Himlin D, De Petris G, Aqel BA, Byrne TJ, Carey EJ, Douglas DD, Mulligan DC, Silva AM, Rakela J, Vargas HE. Magnetic resonance elastography can discriminate normal vs. abnormal liver biopsy in candidates for live liver donation. Abdominal Radiology 2014, 40: 795-802. PMID: 25445158, DOI: 10.1007/s00261-014-0310-y.Peer-Reviewed Original ResearchConceptsLive liver donationLiver biopsyLiver donationMagnetic resonance elastographyHepatic steatosisOptimal cutoffExact testPotential live liver donorsAbnormal liver biopsyAbnormal liver histologyLive liver donorsDegree of steatosisDonor evaluation processLiver biopsy resultsROC curveFisher's exact testLiver shear stiffnessAbility of MREResonance elastographyLiver histologyBiopsy resultsLiver donorsLiver fibrosisSteatosisBiopsyWritten informed consent for living liver donor evaluation: Compliance with centers for medicare and medicaid services and organ procurement and transplantation network guidelines and alibi offers
Thiessen C, Kim YA, Yoo PS, Rodriguez‐Davalos M, Mulligan D, Kulkarni S. Written informed consent for living liver donor evaluation: Compliance with centers for medicare and medicaid services and organ procurement and transplantation network guidelines and alibi offers. Liver Transplantation 2014, 20: 416-424. PMID: 24415564, DOI: 10.1002/lt.23822.Peer-Reviewed Original Research
2012
Living donor safety during the performance of hepatectomy
Mulligan DC. Living donor safety during the performance of hepatectomy. Liver Transplantation 2012, 18: 1134-1135. PMID: 22821707, DOI: 10.1002/lt.23514.Peer-Reviewed Original ResearchEndoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy
Hsieh TH, Mekeel KL, Crowell MD, Nguyen CC, Das A, Aqel BA, Carey EJ, Byrne TJ, Vargas HE, Douglas DD, Mulligan DC, Harrison ME. Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy. Gastrointestinal Endoscopy 2012, 77: 47-54. PMID: 23062758, DOI: 10.1016/j.gie.2012.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesBiliary Tract DiseasesBilirubinCholangiopancreatography, Endoscopic RetrogradeCholestasisEndoscopy, Digestive SystemFemaleFollow-Up StudiesHumansLiver TransplantationLiving DonorsMalePostoperative ComplicationsRecurrenceRetrospective StudiesStentsTreatment OutcomeConceptsLiving-donor liver transplantationAnastomotic biliary stricturesEndoscopic retrograde cholangiographyPercutaneous transhepatic cholangiographyBiliary stricturesEndoscopic therapyLiver transplantationEndoscopic treatmentRetrograde cholangiographySurgical revisionRetrospective studyTertiary care academic medical centerAggressive endoscopic approachStent placement strategyUnsuccessful endoscopic therapyDonor liver transplantationOptimal endoscopic treatmentAcademic medical centerDuct anastomosisInitial therapyBile leakageEndoscopic dilationBalloon dilationCommon complicationComplication rate
2011
When Disaster Strikes: Donor Deaths Are Treated With Intense Scrutiny, but Broader Sharing of Information to Benefit All Living Donors Should Be Implemented
Mulligan D, Abecassis M, Johnson M. When Disaster Strikes: Donor Deaths Are Treated With Intense Scrutiny, but Broader Sharing of Information to Benefit All Living Donors Should Be Implemented. American Journal Of Transplantation 2011, 11: 1540-1541. PMID: 21672145, DOI: 10.1111/j.1600-6143.2011.03586.x.Peer-Reviewed Original Research
2010
Living Donor Kidney Transplantation With Multiple Renal Arteries in the Laparoscopic Era
Tyson MD, Castle EP, Ko EY, Andrews PE, Heilman RL, Mekeel KL, Moss AA, Mulligan DC, Reddy KS. Living Donor Kidney Transplantation With Multiple Renal Arteries in the Laparoscopic Era. Urology 2010, 77: 1116-1121. PMID: 21145095, DOI: 10.1016/j.urology.2010.07.503.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansKidney TransplantationLaparoscopyLiving DonorsMaleMiddle AgedRenal ArteryRetrospective StudiesConceptsMultiple renal arteriesSingle renal arterySlow graft functionDonor kidney transplantationPatients' overall survivalGraft functionKidney transplantationRenal arteryOverall survivalSingle tertiary care academic centerTertiary care academic centerLong-term allograftClavien classification systemDelayed graft functionLong-term outcomesAcute rejectionAllograft survivalUrological complicationsPostoperative complicationsRetrospective reviewLaparoscopic eraAnatomic variationsHigh incidenceAcademic centersMRA groupEarly Graft Function After Laparoscopically Procured Living Donor Kidney Transplantation
Tyson M, Castle E, Andrews P, Heilman R, Mekeel K, Moss A, Mulligan D, Reddy K. Early Graft Function After Laparoscopically Procured Living Donor Kidney Transplantation. Journal Of Urology 2010, 184: 1434-1439. PMID: 20727548, DOI: 10.1016/j.juro.2010.06.013.Peer-Reviewed Original ResearchConceptsPoor early graft functionEarly graft functionLiving-donor kidney transplantationGraft functionDonor kidney transplantationAcute rejectionKidney transplantationMultivariate logistic regression modelGraft function groupDelayed graft functionDonor kidney transplantsInstitutional review boardLogistic regression modelsAllograft survivalGraft nephrectomyVascular complicationsKidney transplantPerioperative parametersIndependent predictorsTransplantation databaseClinical outcomesPatient survivalBlack ethnicityMale genderDonor age
2009
Natural history of post–liver transplantation hepatitis C: A review of factors that may influence its course
Gallegos‐Orozco J, Yosephy A, Noble B, Aqel BA, Byrne TJ, Carey EJ, Douglas DD, Mulligan D, Moss A, de Petris G, Williams JW, Rakela J, Vargas HE. Natural history of post–liver transplantation hepatitis C: A review of factors that may influence its course. Liver Transplantation 2009, 15: 1872-1881. PMID: 19938138, DOI: 10.1002/lt.21954.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultBiopsyDisease ProgressionFemaleGraft RejectionHepatitis CHumansKaplan-Meier EstimateLiver CirrhosisLiver FailureLiver TransplantationLiving DonorsMaleMiddle AgedProportional Hazards ModelsRecurrenceRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsEnd-stage liver diseaseHCV-positive recipientsLiver transplantHepatocellular carcinomaHCV recurrenceAcute rejectionPatient survivalBiopsy-proven acute rejectionMedian age 53 yearsHistory of HCCAggressive HCV recurrenceEarly acute rejectionProtocol liver biopsiesSignificant HCV recurrenceAdult liver transplantsAdvanced donor ageAge 53 yearsAge 39 yearsDay of transplantationLong-term survivalElectronic medical recordsAvoidance of rejectionEvaluable populationRapid fibrosersHepatitis CLiving donor liver transplantation and donor graft size: How small can we go to reduce risk to the donor and what is the cost to the recipient?
Mulligan D. Living donor liver transplantation and donor graft size: How small can we go to reduce risk to the donor and what is the cost to the recipient? Liver Transplantation 2009, 15: 1392-1394. PMID: 19877257, DOI: 10.1002/lt.21922.Peer-Reviewed Original Research
2008
Utility of the Endovascular Stapler for Right-Sided Laparoscopic Donor Nephrectomy: A 7-Year Experience at Mayo Clinic
Ko EY, Castle EP, Desai PJ, Moss AA, Reddy KS, Mekeel KL, Mulligan DC, Andrews PE. Utility of the Endovascular Stapler for Right-Sided Laparoscopic Donor Nephrectomy: A 7-Year Experience at Mayo Clinic. Journal Of The American College Of Surgeons 2008, 207: 896-903. PMID: 19183537, DOI: 10.1016/j.jamcollsurg.2008.07.013.Peer-Reviewed Original ResearchConceptsLaparoscopic donor nephrectomyRight laparoscopic donor nephrectomyDonor nephrectomyRight-sided laparoscopic donor nephrectomyRespective recipientsEndovascular gastrointestinal anastomosis staplerFavorable graft outcomesGraft failure rateRenal vascular controlGastrointestinal anastomosis staplerSignificant differencesOutcomes of rightGraft functionGraft outcomePatient demographicsPerioperative variablesVascular complicationsCreatinine levelsRetrospective reviewGIA staplerRenal hilumTransplant teamVascular controlRenal vasculatureMayo ClinicLiving donor liver transplantation in polycystic liver disease
Mekeel KL, Moss AA, Reddy KS, Douglas DD, Vargas HE, Carey EJ, Byrne TJ, Harrison ME, Rakela J, Mulligan DC. Living donor liver transplantation in polycystic liver disease. Liver Transplantation 2008, 14: 680-683. PMID: 18433036, DOI: 10.1002/lt.21423.Peer-Reviewed Original ResearchConceptsPolycystic liver diseaseDonor liver transplantationLiver transplantationLiver diseaseLiver functionEnd-Stage Liver Disease (MELD) systemDeceased donor liver transplantDonor liver transplantLiver transplantCaval resectionPoor qualityMassive hepatomegalyPatient survivalLiving donationPatientsHepatomegalyTransplantationHepatectomyDiseaseIdeal optionLDLTResectionComplicationsTransplantGraft
2007
Coccidioidomycosis in healthy persons evaluated for liver or kidney donation
Blair JE, Mulligan DC. Coccidioidomycosis in healthy persons evaluated for liver or kidney donation. Transplant Infectious Disease 2007, 9: 78-82. PMID: 17313480, DOI: 10.1111/j.1399-3062.2006.00179.x.Peer-Reviewed Original ResearchConceptsDonor-derived coccidioidomycosisKidney donationTransplant recipientsHealthy personsDonor candidatesOrgan donor candidatesRisk of transmissionProphylaxis protocolLiver donationFourth patientCoccidioidal antibodiesPossible liverCoccidioidomycosisFungal infectionsCoccidioides speciesRecipientsFurther studiesPatientsLiverRiskDonationProphylaxisUnique challengesInfectionPrevalence
2006
A worldwide database for living donor liver transplantation is long overdue
Mulligan DC. A worldwide database for living donor liver transplantation is long overdue. Liver Transplantation 2006, 12: 1443-1444. PMID: 17004258, DOI: 10.1002/lt.20925.Peer-Reviewed Original ResearchLiving donor liver transplantation for hepatitis C‐related cirrhosis: No difference in histological recurrence when compared to deceased donor liver transplantation recipients
Guo L, Orrego M, Rodriguez‐Luna H, Balan V, Byrne T, Chopra K, Douglas DD, Harrison E, Moss A, Reddy KS, Williams JW, Rakela J, Mulligan D, Vargas HE. Living donor liver transplantation for hepatitis C‐related cirrhosis: No difference in histological recurrence when compared to deceased donor liver transplantation recipients. Liver Transplantation 2006, 12: 560-565. PMID: 16555313, DOI: 10.1002/lt.20660.Peer-Reviewed Original ResearchConceptsDeceased donor liver transplantationDonor liver transplantationLiver transplantationHistological recurrenceHepatitis CDeceased-donor liver transplantation (DDLT) recipientsEnd-stage liver disease (MELD) scoreDonor liver transplantation recipientsHepatitis C virus infectionKaplan-Meier survival analysisDetectable HCV RNAHistological recurrence rateC virus infectionGraft survival ratesLiver Disease scoreActivity of inflammationLiver transplantation recipientsStatistical differenceChild-TurcotteDDLT groupLDLT patientsPugh scoreRecurrent HCVLiver transplantYears posttransplantation
2005
A Comparison of Transfusion Requirements Between Living Donation and Cadaveric Donation Liver Transplantation: Relationship to Model of End-Stage Liver Disease Score and Baseline Coagulation Status
Frasco PE, Poterack KA, Hentz JG, Mulligan DC. A Comparison of Transfusion Requirements Between Living Donation and Cadaveric Donation Liver Transplantation: Relationship to Model of End-Stage Liver Disease Score and Baseline Coagulation Status. Anesthesia & Analgesia 2005, 101: 30-37. PMID: 15976201, DOI: 10.1213/01.ane.0000155288.57914.0d.Peer-Reviewed Original ResearchConceptsEnd-stage liver disease (MELD) scoreLiver Disease scoreComponent therapyTransplant patientsMELD scoreRed blood cellsDonation transplantationDonation transplantsIntraoperative transfusionCoagulation functionBlood cellsDisease scoreBaseline coagulation statusPreoperative fibrinogen concentrationLow MELD scoresTime of transplantationPreoperative coagulation testsSeverity of diseaseDegree of impairmentTransfusion exposureTransfusion requirementsLiver transplantLiver transplantationCoagulation statusTransplantation recipients
2004
Hepatopulmonary syndrome after living donor liver transplantation and deceased donor liver transplantation: A single‐center experience
Carey EJ, Douglas DD, Balan V, Vargas HE, Byrne TJ, Moss AA, Mulligan DC. Hepatopulmonary syndrome after living donor liver transplantation and deceased donor liver transplantation: A single‐center experience. Liver Transplantation 2004, 10: 529-533. PMID: 15048796, DOI: 10.1002/lt.20127.Peer-Reviewed Original ResearchConceptsDeceased donor liver transplantationDonor liver transplantationHepatopulmonary syndromeLiver transplantationShunt fractionEnd-stage liver diseaseLiver transplant recipientsSingle-center experienceNormal pulmonary functionMean shunt fractionTransplant recipientsMean PaO2Pulmonary functionLiver diseaseSingle centerSupplemental oxygenNatural courseTransplantationHepatic regenerationSmall seriesPatientsLDLTPaO2SyndromeComplications