2002
Activation Time Course of Activator Protein-1 and Effect of Proline Dithiocarbamate During Ischemia-Reperfusion in Rat Skeletal Muscle
Lefler SR, Lille ST, Huemer G, Tucker R, Murray T, Schoeller T, Mulligan DC. Activation Time Course of Activator Protein-1 and Effect of Proline Dithiocarbamate During Ischemia-Reperfusion in Rat Skeletal Muscle. Annals Of Plastic Surgery 2002, 49: 654-659. PMID: 12461450, DOI: 10.1097/00000637-200212000-00016.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAP-1 activationRat skeletal muscleActivator protein-1Nuclear factor-kappa B (NF-κB) inhibitorSkeletal muscleAP-1Hours of reperfusionProtein 1Proline dithiocarbamateIschemia reperfusionIschemic periodIntravenous administrationBiphasic patternB inhibitorReperfusionActivation time courseFurther elucidationTime courseInjuryExpression of genesPerfusionDeleterious effectsMuscleHoursAmelioration of hepatic ischemia/reperfusion injury using indolepropionic acid
Lefler SR, St. Peter SD, Rodriguez-Davalos MI, Perumean JC, Spence NA, Moss AA, Mulligan DC. Amelioration of hepatic ischemia/reperfusion injury using indolepropionic acid. Transplantation Proceedings 2002, 34: 3065-3066. PMID: 12493376, DOI: 10.1016/s0041-1345(02)03616-3.Peer-Reviewed Original Research
2001
Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury
Lille S, Lefler S, Mowlavi A, Suchy H, Boyle E, Farr A, Su C, Frank N, Mulligan D. Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury. Muscle & Nerve 2001, 24: 534-541. PMID: 11268026, DOI: 10.1002/mus.1037.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injuryNF-kappaB activationNF-kappaBReperfusion injurySevere ischemic stressNF-κB activityNuclear factor-kappaBRat skeletal muscleR injuryEarly reperfusionIschemic periodNeutrophil activityMuscle edemaIntravenous administrationIschemic stressReperfusionTherapeutic interventionsFactor-kappaBMuscle survivalIncreased percentageBiphasic patternInjurySkeletal muscleRat muscleActivity levels