2022
L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusion
2018
Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model
Finotti M, Lysyy T, Barahona M, Maina R, Caturegli G, D'Amico F, Mulligan D, Geibel J. Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model. Transplantation 2018, 102: s709. DOI: 10.1097/01.tp.0000543675.85457.d2.Peer-Reviewed Original ResearchIschemia-reperfusion injuryIschemic injuryIschemic damageL-arginineSmall intestineL-NAMEDistal colonPerfusion machineMale Sprague-Dawley ratsIntestinal ischemic damageIntestinal ischemic injuryAnti-ischemic effectsSprague-Dawley ratsIntestinal graftInflammatory injuryInflammatory pathwaysIntestinal viabilityProtective effectAbdominal cavityColon segmentsIschemic conditionsIntestinal wallIntraluminal secretionsAnimal modelsIntestine segments