Activation of the Calcium Sensing Receptor (casr) Prevents Secretagogue-Induced Diarrhea in the Rat Small Intestine
Finotti M, Lysyy T, Caturegli G, Barahona M, Maina R, D'Amico F, Mulligan D, Geibel J. Activation of the Calcium Sensing Receptor (casr) Prevents Secretagogue-Induced Diarrhea in the Rat Small Intestine. Transplantation 2018, 102: s669. DOI: 10.1097/01.tp.0000543607.00911.f4.Peer-Reviewed Original ResearchOral rehydration solutionSmall intestineColon segmentsIntestinal secretionNumerous body tissuesSeverity of diarrheaDistal small intestineMale Sprague-DawleyCalcium-sensing receptorDistal portionLuminal calcium concentrationRat small intestineAbsence of forskolinCalcium perfusionProphylactic therapyAntibiotic therapyLeading causePotent secretagogueRehydration solutionSprague-DawleyElectrolyte homeostasisDiarrheaPotential treatmentSecretion profileAbsorption of fluid