2020
Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions
Lysyy T, Finotti M, Maina RM, Morotti R, Munoz-Abraham AS, Bertacco A, Ibarra C, Barahona M, Agarwal R, D'Amico F, Rodriguez-Davalos MI, Mulligan D, Geibel J. Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions. Transplantation Proceedings 2020, 52: 2934-2940. PMID: 32768284, DOI: 10.1016/j.transproceed.2020.06.031.Peer-Reviewed Original ResearchConceptsContinuous perfusion preservationIntestinal graftIschemic damagePerfusion preservationAppropriate graft selectionCold static storageSmall intestinal graftsSmall intestine graftDifferent preservation solutionsBlinded histological evaluationCross clampIntestine graftsPostoperative complicationsDifferent time pointsIschemic injuryDeceased donorsPatient survivalGraft selectionRinger's lactateHistological evaluationBack tableVascular perfusionLuminal flushAbdominal organsSmall intestine
2018
Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model
Finotti M, Lysyy T, Barahona M, Maina R, Caturegli G, D'Amico F, Mulligan D, Geibel J. Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model. Transplantation 2018, 102: s709. DOI: 10.1097/01.tp.0000543675.85457.d2.Peer-Reviewed Original ResearchIschemia-reperfusion injuryIschemic injuryIschemic damageL-arginineSmall intestineL-NAMEDistal colonPerfusion machineMale Sprague-Dawley ratsIntestinal ischemic damageIntestinal ischemic injuryAnti-ischemic effectsSprague-Dawley ratsIntestinal graftInflammatory injuryInflammatory pathwaysIntestinal viabilityProtective effectAbdominal cavityColon segmentsIschemic conditionsIntestinal wallIntraluminal secretionsAnimal modelsIntestine segments