2022
L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusion
2017
Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury
Bertacco A, Dehner CA, Caturegli G, D'Amico F, Morotti R, Rodriguez MI, Mulligan DC, Kriegel MA, Geibel JP. Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury. Frontiers In Physiology 2017, 8: 1064. PMID: 29311987, PMCID: PMC5742259, DOI: 10.3389/fphys.2017.01064.Peer-Reviewed Original ResearchIschemic injuryIntestinal ischemiaProtective effectIntestinal ischemic injuryLight-level microscopyEosin-stained sectionsLactate administrationAntibiotic treatmentIschemic protectionIntestinal barrierLactate perfusionRat modelIntestinal microbiomeIntestinal preservationIntestinal segmentsIschemic cellsSmall intestineInert sugarsInjuryIschemiaPerfusionEpithelium morphologySecretionPerfusion deviceFITC-inulin
2012
Impact of Using Deceased Donor Kidneys with Acute Kidney Injury (AKI) on 1-Year Protocol Biopsy Findings
Heilman R, Smith M, Chakkera H, Khamash H, Hamawi K, Moss A, Katariya N, Mulligan D, Reddy K. Impact of Using Deceased Donor Kidneys with Acute Kidney Injury (AKI) on 1-Year Protocol Biopsy Findings. Transplantation 2012, 94: 243. DOI: 10.1097/00007890-201211271-00453.Peer-Reviewed Original ResearchBaseline Biopsy Findings and Clinical Outcomes in Recipients of Kidneys from Standard Criteria Donors (SCD) with Acute Kidney Injury (AKI)
Reddy K, Smith M, Chakkera H, Moss A, Mulligan D, Khamash H, Hewitt W, Katariya N, Heilman R. Baseline Biopsy Findings and Clinical Outcomes in Recipients of Kidneys from Standard Criteria Donors (SCD) with Acute Kidney Injury (AKI). Transplantation 2012, 94: 341. DOI: 10.1097/00007890-201211271-00631.Peer-Reviewed Original ResearchImpact of Using Deceased Donor Kidneys with Acute Kidney Injury (AKI) on 1-Year Protocol Biopsy Findings
Heilman R, Smith M, Chakkera H, Khamash H, Hamawi K, Moss A, Katariya N, Mulligan D, Reddy K. Impact of Using Deceased Donor Kidneys with Acute Kidney Injury (AKI) on 1-Year Protocol Biopsy Findings. Transplantation 2012, 94: 1021. DOI: 10.1097/00007890-201211271-02021.Peer-Reviewed Original Research
2007
Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy
Mekeel KL, Mazur MJ, Reddy KS, Mulligan DC, Heilman RL, Chakkera HA, Andrews PE, Moss AA. Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy. American Journal Of Transplantation 2007, 7: 2039-2041. PMID: 17578504, DOI: 10.1111/j.1600-6143.2007.01870.x.Peer-Reviewed Original ResearchConceptsDonor nephrectomyUrine leakRecipient graft functionGood renal functionLaparoscopic donor nephrectomyComplete deglovingGraft functionKidney transplantationPostoperative courseRenal functionPeritoneal windowLarge urinomaGlue treatmentKidneyUnconcentrated urineKidney surfaceNephrectomyLeakUrinomaPatientsTransplantationDeglovingInjuryTraumaUrine
2003
Effects of tacrolimus on ischemia‐reperfusion injury
St. Peter SD, Moss AA, Mulligan DC. Effects of tacrolimus on ischemia‐reperfusion injury. Liver Transplantation 2003, 9: 105-116. PMID: 12548502, DOI: 10.1053/jlts.2003.50020.Peer-Reviewed Original ResearchConceptsEffects of tacrolimusIschemia-reperfusion injuryCellular mechanismsCalcium-activated pathwaysInteractions of tacrolimusFree radical metabolismCornerstone agentEfficacious immunosuppressionInflammatory cascadeOrgan transplantationTacrolimusCytoprotective effectsTissue recoveryClinical literatureDiverse actionsRadical metabolismImmunosuppressionInjuryMitochondrial stabilityStress response proteinsReperfusionIschemiaTransplantationTranscription factorsMicrocirculation
2002
Activation Time Course of Activator Protein-1 and Effect of Proline Dithiocarbamate During Ischemia-Reperfusion in Rat Skeletal Muscle
Lefler SR, Lille ST, Huemer G, Tucker R, Murray T, Schoeller T, Mulligan DC. Activation Time Course of Activator Protein-1 and Effect of Proline Dithiocarbamate During Ischemia-Reperfusion in Rat Skeletal Muscle. Annals Of Plastic Surgery 2002, 49: 654-659. PMID: 12461450, DOI: 10.1097/00000637-200212000-00016.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAP-1 activationRat skeletal muscleActivator protein-1Nuclear factor-kappa B (NF-κB) inhibitorSkeletal muscleAP-1Hours of reperfusionProtein 1Proline dithiocarbamateIschemia reperfusionIschemic periodIntravenous administrationBiphasic patternB inhibitorReperfusionActivation time courseFurther elucidationTime courseInjuryExpression of genesPerfusionDeleterious effectsMuscleHours
2001
Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury
Lille S, Lefler S, Mowlavi A, Suchy H, Boyle E, Farr A, Su C, Frank N, Mulligan D. Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury. Muscle & Nerve 2001, 24: 534-541. PMID: 11268026, DOI: 10.1002/mus.1037.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injuryNF-kappaB activationNF-kappaBReperfusion injurySevere ischemic stressNF-κB activityNuclear factor-kappaBRat skeletal muscleR injuryEarly reperfusionIschemic periodNeutrophil activityMuscle edemaIntravenous administrationIschemic stressReperfusionTherapeutic interventionsFactor-kappaBMuscle survivalIncreased percentageBiphasic patternInjurySkeletal muscleRat muscleActivity levels