2019
Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers
Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y. Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers. Neuropsychopharmacology 2019, 44: 1714-1719. PMID: 30928993, PMCID: PMC6785144, DOI: 10.1038/s41386-019-0379-7.Peer-Reviewed Original ResearchConceptsBody mass indexKappa-opioid receptorsPositron emission tomographyAgonist radiotracerKOR systemOpioid receptorsTime-activity curvesBarratt Simplified MeasureAnterior cingulate cortexArterial blood samplingMultilinear analysis-1 (MA1) methodPET imaging studiesKOR levelsMass indexPreclinical modelsFrontal cortexHealthy volunteersRegional time-activity curvesBlood samplingPET scansCingulate cortexImaging studiesEmission tomographyVentral striatumRegional volumes
2017
389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study
Esterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study. Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.Peer-Reviewed Original ResearchMetabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study
Abdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I. Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 449-456. PMID: 28993818, PMCID: PMC5630181, DOI: 10.1016/j.bpsc.2017.03.019.Peer-Reviewed Original ResearchMajor depressive disorderMetabotropic glutamate receptor 5Positron emission tomographyGlutamate receptor 5Healthy controlsGlx levelsMGluR5 availabilityDepressive disorderReceptor 5Glx/Cr levelsAnterior cingulate glutamateGlutamate/CrRole of mGluR5Proton magnetic resonance spectroscopyDistribution volume ratioMultimodal Imaging StudyACC glutamateGlutamatergic systemGlutamate involvementGlutamate levelsPostmortem studiesEmission tomographyImaging studiesMGluR5Cr levels
2013
Gray matter volume correlates of global positive alcohol expectancy in non‐dependent adult drinkers
Ide JS, Zhang S, Hu S, Matuskey D, Bednarski SR, Erdman E, Farr OM, Li C. Gray matter volume correlates of global positive alcohol expectancy in non‐dependent adult drinkers. Addiction Biology 2013, 19: 895-906. PMID: 23461484, PMCID: PMC3681829, DOI: 10.1111/adb.12046.Peer-Reviewed Original ResearchConceptsGM volumeVoxel-based morphometrySuperior frontal gyrusPrecentral gyrusBilateral superior frontal gyrusBilateral dorsolateral prefrontal cortexStructural brain changesNumerous imaging studiesLeft precentral gyrusGray matter volumeDrinking behaviorRight ventral putamenDorsolateral prefrontal cortexNon-dependent drinkersStructural brain correlatesVentral putamenBrain changesFrontal cortexGray matter correlatesMatter volumeNon-dependent drinkingRecent drinkingImaging studiesInfluence drinking behaviorPrefrontal cortex
2012
Age Effects on Serotonin Receptor 1B as Assessed by PET
Matuskey D, Pittman B, Planeta-Wilson B, Walderhaug E, Henry S, Gallezot JD, Nabulsi N, Ding YS, Bhagwagar Z, Malison R, Carson RE, Neumeister A. Age Effects on Serotonin Receptor 1B as Assessed by PET. Journal Of Nuclear Medicine 2012, 53: 1411-1414. PMID: 22851636, PMCID: PMC3690814, DOI: 10.2967/jnumed.112.103598.Peer-Reviewed Original ResearchConceptsMultilinear reference tissue modelGray matter atrophyReceptor 1BAge-related gray matter atrophyIndividual cortical regionsSerotonin receptor 1BPrevious imaging studiesSerotonin measuresReference tissue modelAge-related declineMatter atrophyHealthy subjectsHealthy adultsGray matterImaging studiesCortical regionsPET imagingSubject underwentMultiple comparisonsCortexNegative associationAge effectsAgeAtrophyPutamen