2017
Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements
Kelada OJ, Rockwell S, Zheng MQ, Huang Y, Liu Y, Booth CJ, Decker RH, Oelfke U, Carson RE, Carlson DJ. Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements. Molecular Imaging And Biology 2017, 19: 893-902. PMID: 28409339, PMCID: PMC5640490, DOI: 10.1007/s11307-017-1083-9.Peer-Reviewed Original ResearchConceptsPositron emission tomographyTumor hypoxic fractionHypoxic fractionEmission tomographyLung cancer radiotherapy patientsPO2 measurementsAbsolute tumor volumeC miceDirect pO2 measurementsBlood ratioClinical impactTumor volumeHypoxia quantificationSubcutaneous tumorsPurposeThe purposeTracer kinetic modelingRadiotherapy patientsPET imagingPatientsPO2 valuesScansPatlak modelTomographyTwo-compartmentTBR
2016
Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization
Song C, Hong BJ, Bok S, Lee CJ, Kim YE, Jeon SR, Wu HG, Lee YS, Cheon GJ, Paeng JC, Carlson DJ, Kim HJ, Ahn GO. Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization. International Journal Of Radiation Oncology • Biology • Physics 2016, 95: 1022-1031. PMID: 27130790, DOI: 10.1016/j.ijrobp.2016.01.064.Peer-Reviewed Original ResearchConceptsStereotactic ablative radiation therapyTumor/brain ratiosAblative radiation therapyRadiation therapyDay 0Day 6Brain ratioSingle doseVascular collapseHigh-dose irradiationDay 2Single high-dose irradiationHigh-dose radiation therapyTumor hypoxiaSyngeneic Lewis lung carcinomaHoechst 33342 perfusionTumor oxygenation changesRadiation therapy schedulesLewis lung carcinomaOrthotopic lung tumorsOptimal fractionation schedulePositron emission tomography (PET) imagingEmission Tomography ImagingTumor hypoxia levelsFluorescence-activated cell
2015
Synthesis of [18F]FMISO in a flow-through microfluidic reactor: Development and clinical application
Zheng MQ, Collier L, Bois F, Kelada OJ, Hammond K, Ropchan J, Akula MR, Carlson DJ, Kabalka GW, Huang Y. Synthesis of [18F]FMISO in a flow-through microfluidic reactor: Development and clinical application. Nuclear Medicine And Biology 2015, 42: 578-584. PMID: 25779036, DOI: 10.1016/j.nucmedbio.2015.01.010.Peer-Reviewed Original Research
2010
Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2010, 79: 1188-1195. PMID: 21183291, PMCID: PMC3053128, DOI: 10.1016/j.ijrobp.2010.10.007.Peer-Reviewed Original ResearchConceptsTumor cell killingTumor hypoxiaCell killingRadiation fractionation schemesTumor biological effective doseBiological effective doseTumor cell killRegions of hypoxiaRadiotherapy regimenTreatment failureConventional fractionationNeck cancerStandard fractionationProstate cancerTumor cell populationFractionation schemeRadiation therapyTumor clonogensTumor oxygenationBlood vessels resultsCell killEffective doseAlternate fractionationResistant cellsHypoxia
2009
DMLC motion tracking of moving targets for intensity modulated arc therapy treatment – a feasibility study
Zimmerman J, Korreman S, Persson G, Cattell H, Svatos M, Sawant A, Venkat R, Carlson D, Keall P. DMLC motion tracking of moving targets for intensity modulated arc therapy treatment – a feasibility study. Acta Oncologica 2009, 48: 245-250. PMID: 18720056, DOI: 10.1080/02841860802266722.Peer-Reviewed Original Research