2016
Biologically optimized helium ion plans: calculation approach and its in vitro validation
Mairani A, Dokic I, Magro G, Tessonnier T, Kamp F, Carlson DJ, Ciocca M, Cerutti F, Sala PR, Ferrari A, Böhlen TT, Jäkel O, Parodi K, Debus J, Abdollahi A, Haberer T. Biologically optimized helium ion plans: calculation approach and its in vitro validation. Physics In Medicine And Biology 2016, 61: 4283-4299. PMID: 27203864, DOI: 10.1088/0031-9155/61/11/4283.Peer-Reviewed Original Research
2015
Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra
Kamp F, Cabal G, Mairani A, Parodi K, Wilkens JJ, Carlson DJ. Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 557-568. PMID: 26460998, DOI: 10.1016/j.ijrobp.2015.07.2264.Peer-Reviewed Original ResearchConceptsRelative biological effectivenessCarbon ion therapyCarbon ionsIon therapyHeavy ion treatment planningMonte Carlo code FLUKAPrimary carbon ionsCarbon ion energyRadiation therapy beamsRBE valuesCarbon ion treatment plansRelevant RBE valuesRMF predictionsHeavy ionsIon energyDouble-strand break (DSB) yieldsRMF modelEnergy spectrumTherapy beamsSecondary fragmentsMonte Carlo damage simulationNuclear fragmentsBiological optimizationBiological effectivenessRBE predictions
2014
The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?
Brown JM, Carlson DJ, Brenner DJ. The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved? International Journal Of Radiation Oncology • Biology • Physics 2014, 88: 254-262. PMID: 24411596, PMCID: PMC3893711, DOI: 10.1016/j.ijrobp.2013.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsCell CycleCell HypoxiaCell ProliferationCell SurvivalDNA DamageDNA RepairDose Fractionation, RadiationEndothelial CellsHumansLinear ModelsMelanomaMiceModels, BiologicalNeoplasmsOxygen ConsumptionRadiation ToleranceRadiobiologyRadiosurgeryRelative Biological Effectiveness
2011
A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy
Frese MC, Yu VK, Stewart RD, Carlson DJ. A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2011, 83: 442-450. PMID: 22099045, DOI: 10.1016/j.ijrobp.2011.06.1983.Peer-Reviewed Original ResearchConceptsRelative biological effectivenessCarbon ionsRadiation qualityUniform biological effectIon kinetic energyBiological effectivenessMonte Carlo modelParticle energyRMF modelBragg peakMonte Carlo damage simulation (MCDS) softwareCarlo modelRelevant protonsLinear-quadratic parametersKinetic energyProton relative biological effectivenessProtonsPhysical doseParticle distributionIonsParameter αEnergyRepresentative spreadSOBPPotential biological advantagesEffects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death
Stewart RD, Yu VK, Georgakilas AG, Koumenis C, Park JH, Carlson DJ. Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death. Radiation Research 2011, 176: 587-602. PMID: 21823972, DOI: 10.1667/rr2663.1.Peer-Reviewed Original Research
2010
Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2010, 79: 1188-1195. PMID: 21183291, PMCID: PMC3053128, DOI: 10.1016/j.ijrobp.2010.10.007.Peer-Reviewed Original ResearchConceptsTumor cell killingTumor hypoxiaCell killingRadiation fractionation schemesTumor biological effective doseBiological effective doseTumor cell killRegions of hypoxiaRadiotherapy regimenTreatment failureConventional fractionationNeck cancerStandard fractionationProstate cancerTumor cell populationFractionation schemeRadiation therapyTumor clonogensTumor oxygenationBlood vessels resultsCell killEffective doseAlternate fractionationResistant cellsHypoxia
2008
Combined Use of Monte Carlo DNA Damage Simulations and Deterministic Repair Models to Examine Putative Mechanisms of Cell Killing
Carlson DJ, Stewart RD, Semenenko VA, Sandison GA. Combined Use of Monte Carlo DNA Damage Simulations and Deterministic Repair Models to Examine Putative Mechanisms of Cell Killing. Radiation Research 2008, 169: 447-459. PMID: 18363426, DOI: 10.1667/rr1046.1.Peer-Reviewed Original Research
2006
Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear‐quadratic (LQ) model parametersa)
Carlson DJ, Stewart RD, Semenenko VA. Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear‐quadratic (LQ) model parametersa). Medical Physics 2006, 33: 3105-3115. PMID: 17022202, DOI: 10.1118/1.2229427.Peer-Reviewed Original ResearchConceptsSurvival dataHypoxic cellsOxygen enhancement ratioPatient survival dataIntrinsic radiation sensitivityPoor treatment prognosisSublethal damage repairTumor controlHypoxic subvolumesCervix cancerClinical dataRadiosensitivity parametersTreatment prognosisAerobic cellsDoseDecreased sensitivityHypoxiaEnhancement ratioHypoxicTumorsAlpha/CellsLow-LET radiationTumor regionRadiation sensitivity