2015
High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients
Shuryak I, Carlson DJ, Brown JM, Brenner DJ. High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients. Radiotherapy And Oncology 2015, 115: 327-334. PMID: 26058991, DOI: 10.1016/j.radonc.2015.05.013.Peer-Reviewed Original ResearchConceptsMulti-fraction stereotactic radiotherapyStereotactic radiotherapyTumoricidal mechanismsTumor controlHigh dosesSingle-dose stereotactic radiotherapySingle-fraction treatmentStereotactic radiation therapyTumor control dataBrain metastasesLung tumorsSRT patientsRadiation therapyTreatment dosesLow dosesSRT treatmentDosesLinear-quadratic modelPatientsFraction numberTreatmentLung dataLQ modelControl dataMetastasis
2014
The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?
Brown JM, Carlson DJ, Brenner DJ. The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved? International Journal Of Radiation Oncology • Biology • Physics 2014, 88: 254-262. PMID: 24411596, PMCID: PMC3893711, DOI: 10.1016/j.ijrobp.2013.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsCell CycleCell HypoxiaCell ProliferationCell SurvivalDNA DamageDNA RepairDose Fractionation, RadiationEndothelial CellsHumansLinear ModelsMelanomaMiceModels, BiologicalNeoplasmsOxygen ConsumptionRadiation ToleranceRadiobiologyRadiosurgeryRelative Biological Effectiveness
2011
A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy
Frese MC, Yu VK, Stewart RD, Carlson DJ. A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2011, 83: 442-450. PMID: 22099045, DOI: 10.1016/j.ijrobp.2011.06.1983.Peer-Reviewed Original ResearchConceptsRelative biological effectivenessCarbon ionsRadiation qualityUniform biological effectIon kinetic energyBiological effectivenessMonte Carlo modelParticle energyRMF modelBragg peakMonte Carlo damage simulation (MCDS) softwareCarlo modelRelevant protonsLinear-quadratic parametersKinetic energyProton relative biological effectivenessProtonsPhysical doseParticle distributionIonsParameter αEnergyRepresentative spreadSOBPPotential biological advantages
2010
Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2010, 79: 1188-1195. PMID: 21183291, PMCID: PMC3053128, DOI: 10.1016/j.ijrobp.2010.10.007.Peer-Reviewed Original ResearchConceptsTumor cell killingTumor hypoxiaCell killingRadiation fractionation schemesTumor biological effective doseBiological effective doseTumor cell killRegions of hypoxiaRadiotherapy regimenTreatment failureConventional fractionationNeck cancerStandard fractionationProstate cancerTumor cell populationFractionation schemeRadiation therapyTumor clonogensTumor oxygenationBlood vessels resultsCell killEffective doseAlternate fractionationResistant cellsHypoxia
2006
Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear‐quadratic (LQ) model parametersa)
Carlson DJ, Stewart RD, Semenenko VA. Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear‐quadratic (LQ) model parametersa). Medical Physics 2006, 33: 3105-3115. PMID: 17022202, DOI: 10.1118/1.2229427.Peer-Reviewed Original ResearchConceptsSurvival dataHypoxic cellsOxygen enhancement ratioPatient survival dataIntrinsic radiation sensitivityPoor treatment prognosisSublethal damage repairTumor controlHypoxic subvolumesCervix cancerClinical dataRadiosensitivity parametersTreatment prognosisAerobic cellsDoseDecreased sensitivityHypoxiaEnhancement ratioHypoxicTumorsAlpha/CellsLow-LET radiationTumor regionRadiation sensitivity