2017
Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements
Kelada OJ, Rockwell S, Zheng MQ, Huang Y, Liu Y, Booth CJ, Decker RH, Oelfke U, Carson RE, Carlson DJ. Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements. Molecular Imaging And Biology 2017, 19: 893-902. PMID: 28409339, PMCID: PMC5640490, DOI: 10.1007/s11307-017-1083-9.Peer-Reviewed Original ResearchConceptsPositron emission tomographyTumor hypoxic fractionHypoxic fractionEmission tomographyLung cancer radiotherapy patientsPO2 measurementsAbsolute tumor volumeC miceDirect pO2 measurementsBlood ratioClinical impactTumor volumeHypoxia quantificationSubcutaneous tumorsPurposeThe purposeTracer kinetic modelingRadiotherapy patientsPET imagingPatientsPO2 valuesScansPatlak modelTomographyTwo-compartmentTBR
2014
WE‐G‐BRD‐06: Variation in Dynamic Positron Emission Tomography Imaging of Tumor Hypoxia in Early Stage Non‐Small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy
Kelada O, Decker R, Zheng M, Huang Y, Xia Y, Gallezot J, Liu C, Rockwell S, Carson R, Oelfke U, Carlson D. WE‐G‐BRD‐06: Variation in Dynamic Positron Emission Tomography Imaging of Tumor Hypoxia in Early Stage Non‐Small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy. Medical Physics 2014, 41: 520-520. DOI: 10.1118/1.4889490.Peer-Reviewed Original ResearchNon-small cell lung cancer patientsCell lung cancer patientsPositron emission tomographyTumor hypoxic volumeLung cancer patientsCancer patientsHypoxic volumeEarly stage non-small cell lung cancer patientsTumor hypoxiaTumor vascular responseStereotactic body radiotherapyTotal tumor volumeNovel pilot studyEmission Tomography ImagingPositron emission tomography (PET) imagingDifferent time pointsTreatment failureFirst patientVascular responsesBody radiotherapyNSCLC tumorsTreatment individualizationBlood ratioTumor volumeSingle patientMolecular Imaging of Tumor Hypoxia with Positron Emission Tomography
Kelada OJ, Carlson DJ. Molecular Imaging of Tumor Hypoxia with Positron Emission Tomography. Radiation Research 2014, 181: 335-349. PMID: 24673257, PMCID: PMC5555673, DOI: 10.1667/rr13590.1.Peer-Reviewed Original ResearchConceptsTumor hypoxiaOncology communityTumor hypoxic volumeImportant prognostic factorOverall treatment responseRisk of metastasisTypes of tumorsEmission Tomography ImagingPositron emission tomography (PET) imagingClinical oncology communityPositron emission tomographyConventional cancer therapiesMagnitude of hypoxiaPrognostic factorsCancer patientsTreatment responseField of PETChemotherapy resistanceEmission tomographyClinical settingRadiolabelled agentsCancer typesPatientsHypoxia tracerHypoxia
2013
MO‐D‐141‐01: Quantification of Tumor Hypoxia Using [18F]‐Fluoromisonidazole Positron Emission Tomography and Tracer Kinetic Modeling
Kelada O, Rockwell S, Carson R, Decker R, Oelfke U, Carlson D. MO‐D‐141‐01: Quantification of Tumor Hypoxia Using [18F]‐Fluoromisonidazole Positron Emission Tomography and Tracer Kinetic Modeling. Medical Physics 2013, 40: 399-399. DOI: 10.1118/1.4815248.Peer-Reviewed Original ResearchPositron emission tomographyBlood ratioComputed tomographyFluoromisonidazole positron emission tomographyMale BALB/c miceEmission tomographyTumor hypoxiaBALB/c miceEMT-6 tumorsNon-invasive imaging methodVoxel basisTreatment failureC miceConventional tumorHypoxia quantificationHypoxic fractionAnaesthetized animalsTumorsHistologic sectionsPharmacokinetic modelPharmacokinetic modelingDynamic positron emission tomographyPET imagingHypoxic radioresistanceBetter delineation