2016
Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization
Song C, Hong BJ, Bok S, Lee CJ, Kim YE, Jeon SR, Wu HG, Lee YS, Cheon GJ, Paeng JC, Carlson DJ, Kim HJ, Ahn GO. Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization. International Journal Of Radiation Oncology • Biology • Physics 2016, 95: 1022-1031. PMID: 27130790, DOI: 10.1016/j.ijrobp.2016.01.064.Peer-Reviewed Original ResearchConceptsStereotactic ablative radiation therapyTumor/brain ratiosAblative radiation therapyRadiation therapyDay 0Day 6Brain ratioSingle doseVascular collapseHigh-dose irradiationDay 2Single high-dose irradiationHigh-dose radiation therapyTumor hypoxiaSyngeneic Lewis lung carcinomaHoechst 33342 perfusionTumor oxygenation changesRadiation therapy schedulesLewis lung carcinomaOrthotopic lung tumorsOptimal fractionation schedulePositron emission tomography (PET) imagingEmission Tomography ImagingTumor hypoxia levelsFluorescence-activated cell
2014
WE‐G‐BRD‐06: Variation in Dynamic Positron Emission Tomography Imaging of Tumor Hypoxia in Early Stage Non‐Small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy
Kelada O, Decker R, Zheng M, Huang Y, Xia Y, Gallezot J, Liu C, Rockwell S, Carson R, Oelfke U, Carlson D. WE‐G‐BRD‐06: Variation in Dynamic Positron Emission Tomography Imaging of Tumor Hypoxia in Early Stage Non‐Small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy. Medical Physics 2014, 41: 520-520. DOI: 10.1118/1.4889490.Peer-Reviewed Original ResearchNon-small cell lung cancer patientsCell lung cancer patientsPositron emission tomographyTumor hypoxic volumeLung cancer patientsCancer patientsHypoxic volumeEarly stage non-small cell lung cancer patientsTumor hypoxiaTumor vascular responseStereotactic body radiotherapyTotal tumor volumeNovel pilot studyEmission Tomography ImagingPositron emission tomography (PET) imagingDifferent time pointsTreatment failureFirst patientVascular responsesBody radiotherapyNSCLC tumorsTreatment individualizationBlood ratioTumor volumeSingle patientMolecular Imaging of Tumor Hypoxia with Positron Emission Tomography
Kelada OJ, Carlson DJ. Molecular Imaging of Tumor Hypoxia with Positron Emission Tomography. Radiation Research 2014, 181: 335-349. PMID: 24673257, PMCID: PMC5555673, DOI: 10.1667/rr13590.1.Peer-Reviewed Original ResearchConceptsTumor hypoxiaOncology communityTumor hypoxic volumeImportant prognostic factorOverall treatment responseRisk of metastasisTypes of tumorsEmission Tomography ImagingPositron emission tomography (PET) imagingClinical oncology communityPositron emission tomographyConventional cancer therapiesMagnitude of hypoxiaPrognostic factorsCancer patientsTreatment responseField of PETChemotherapy resistanceEmission tomographyClinical settingRadiolabelled agentsCancer typesPatientsHypoxia tracerHypoxia