Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization
Song C, Hong BJ, Bok S, Lee CJ, Kim YE, Jeon SR, Wu HG, Lee YS, Cheon GJ, Paeng JC, Carlson DJ, Kim HJ, Ahn GO. Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization. International Journal Of Radiation Oncology • Biology • Physics 2016, 95: 1022-1031. PMID: 27130790, DOI: 10.1016/j.ijrobp.2016.01.064.Peer-Reviewed Original ResearchConceptsStereotactic ablative radiation therapyTumor/brain ratiosAblative radiation therapyRadiation therapyDay 0Day 6Brain ratioSingle doseVascular collapseHigh-dose irradiationDay 2Single high-dose irradiationHigh-dose radiation therapyTumor hypoxiaSyngeneic Lewis lung carcinomaHoechst 33342 perfusionTumor oxygenation changesRadiation therapy schedulesLewis lung carcinomaOrthotopic lung tumorsOptimal fractionation schedulePositron emission tomography (PET) imagingEmission Tomography ImagingTumor hypoxia levelsFluorescence-activated cell