2024
Guidelines for Neuroprognostication in Critically Ill Adults with Moderate–Severe Traumatic Brain Injury
Muehlschlegel S, Rajajee V, Wartenberg K, Alexander S, Busl K, Creutzfeldt C, Fontaine G, Hocker S, Hwang D, Kim K, Madzar D, Mahanes D, Mainali S, Meixensberger J, Sakowitz O, Varelas P, Weimar C, Westermaier T. Guidelines for Neuroprognostication in Critically Ill Adults with Moderate–Severe Traumatic Brain Injury. Neurocritical Care 2024, 40: 448-476. PMID: 38366277, PMCID: PMC10959796, DOI: 10.1007/s12028-023-01902-2.Peer-Reviewed Original ResearchTraumatic brain injuryBrain injuryFunctional outcomesSurrogate decision-makersSurrogates of patientsSystematic narrative reviewIMPACT lab modelQuality of evidenceClinical variablesDesirability of outcomesClinically relevant predictorsCritically ill adultsRecommendations AssessmentComfort measuresIn-hospital mortalityConclusionsThese guidelinesMsTBIEligibility criteriaPoor outcomeIll adultsPatient triagePractice recommendationsIndividual predictorsInternational Mission for PrognosisNarrative review
2022
Pilot Randomized Clinical Trial of a Goals-of-Care Decision Aid for Surrogates of Patients With Severe Acute Brain Injury
Muehlschlegel S, Goostrey K, Flahive J, Zhang Q, Pach JJ, Hwang DY. Pilot Randomized Clinical Trial of a Goals-of-Care Decision Aid for Surrogates of Patients With Severe Acute Brain Injury. Neurology 2022, 99: e1446-e1455. PMID: 35853748, PMCID: PMC9576301, DOI: 10.1212/wnl.0000000000200937.Peer-Reviewed Original ResearchConceptsCode status changeTraumatic brain injuryBrain injuryIschemic strokeCare decisionsIntracerebral hemorrhageDA groupAcute brain injury patientsSevere acute brain injuryNeurologic intensive care unitCare decision aidSurrogates of patientsAcute brain injuryAcute ischemic strokeClass IV evidenceLong-term prognosisIntensive care unitBrain injury patientsClinician-family communicationAdditional psychosocial supportPatient-centered careLife-sustaining treatmentPsychological outcomesDecision-making interventionClassification of evidence
2020
Goals-of-care decision aid for critically ill patients with TBI: Development and feasibility testing.
Muehlschlegel S, Hwang DY, Flahive J, Quinn T, Lee C, Moskowitz J, Goostrey K, Jones K, Pach JJ, Knies AK, Shutter L, Goldberg R, Mazor KM. Goals-of-care decision aid for critically ill patients with TBI: Development and feasibility testing. Neurology 2020, 95: e179-e193. PMID: 32554766, PMCID: PMC7455326, DOI: 10.1212/wnl.0000000000009770.Peer-Reviewed Original ResearchConceptsCare decision aidSurrogates of patientsEarly feasibilityFeasibility trial protocolTraumatic brain injuryDecision aidConsecutive patientsIll patientsFeasibility trialStudy protocolTrial protocolBrain injuryInterim analysisCare communicationPatientsPaper-based decision aidExcellent usabilityComplete dataFeasibility testingHigh rateFamily membersBehavioral outcomesQualitative studyAcceptabilityIterative revisions