2016
Recurrent genetic defects in classical Hodgkin lymphoma cell lines
Hudnall SD, Meng H, Lozovatsky L, Li P, Strout M, Kleinstein SH. Recurrent genetic defects in classical Hodgkin lymphoma cell lines. Leukemia & Lymphoma 2016, 57: 2890-2900. PMID: 27121023, DOI: 10.1080/10428194.2016.1177179.Peer-Reviewed Original ResearchConceptsMitosis-related genesSingle nucleotide variantsCHL cell linesCell linesRecurrent genetic defectsPathogenic single nucleotide variantsHL cell linesMitotic genesChromosome duplicationClassical Hodgkin lymphoma cell linesGenomic instabilityGenetic analysisWhole-exome sequencingNucleotide variantsGenesHodgkin's lymphoma cell linesLymphoma cell linesNumber variantsKaryotypic analysisGenetic defectsWealth of informationPoor growthVariantsDuplicationLines
2012
Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma
Siddon A, Lozovatsky L, Mohamed A, Hudnall SD. Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma. British Journal Of Haematology 2012, 158: 635-643. PMID: 22757777, DOI: 10.1111/j.1365-2141.2012.09206.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedBlotting, WesternCell Line, TumorDNA, ViralEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHerpesvirus 6, HumanHodgkin DiseaseHumansImmunohistochemistryLymphoma, FollicularMaleMiddle AgedPolymerase Chain ReactionReed-Sternberg CellsRoseolovirus InfectionsSclerosisYoung AdultConceptsNodular sclerosis Hodgkin lymphomaNodular sclerosis HLHHV-6 DNAEpstein-Barr virusHHV-6Hodgkin's lymphomaReed-Sternberg cellsPolymerase chain reactionRS cellsNSHL casesEBV-negative diseaseReactive lymphoid hyperplasiaClassical Hodgkin lymphomaBi-modal age distributionHHV-6 genomeYounger patientsInfectious etiologyLymphoid hyperplasiaPCR positivityYounger ageImmunohistochemistryMost casesConflicting resultsChain reactionCD30
2008
Herpesvirus prevalence and viral load in healthy blood donors by quantitative real‐time polymerase chain reaction
Hudnall SD, Chen T, Allison P, Tyring SK, Heath A. Herpesvirus prevalence and viral load in healthy blood donors by quantitative real‐time polymerase chain reaction. Transfusion 2008, 48: 1180-1187. PMID: 18422852, DOI: 10.1111/j.1537-2995.2008.01685.x.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusVaricella-zoster virusHealthy adult blood donorsAdult blood donorsBlood donorsHHV-6Human herpesvirusesViral loadHHV-7Primary infectionDonor samplesMedian viral loadHHV-6 DNAHealthy blood donorsHHV-8 DNAViral DNA loadReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHerpes simplex virus 1Single-donor samplesSimplex virus 1Polymerase chain reaction assaysReal-time polymerase chain reaction assaysTransfusion recipientsActive infection
2007
Comparative flow immunophenotypic features of the inflammatory infiltrates of Hodgkin lymphoma and lymphoid hyperplasia
Hudnall SD, Betancourt E, Barnhart E, Patel J. Comparative flow immunophenotypic features of the inflammatory infiltrates of Hodgkin lymphoma and lymphoid hyperplasia. Cytometry Part B Clinical Cytometry 2007, 74B: 1-8. PMID: 18061945, DOI: 10.1002/cyto.b.20376.Peer-Reviewed Original ResearchConceptsRegulatory T cellsMixed cellularity HLReactive lymphoid hyperplasiaB cell ratioHodgkin's lymphomaReactive lymphocytic infiltrateT cellsLymphoid hyperplasiaInflammatory infiltrateB cellsCD8 ratioNKT cellsLymphocytic infiltrateHL subtypesLymph nodesImmunophenotypic featuresCell ratioMixed cellularity Hodgkin's lymphomaMalignant Reed-Sternberg cellsEBV-negative casesLymphocyte depletion subtypeRich inflammatory infiltratePercentage of CD4Fluorochrome-conjugated monoclonal antibodiesReed-Sternberg cells
2006
Anatomical mapping of human herpesvirus reservoirs of infection
Chen T, Hudnall SD. Anatomical mapping of human herpesvirus reservoirs of infection. Modern Pathology 2006, 19: 726-737. PMID: 16528368, DOI: 10.1038/modpathol.3800584.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnal CanalAutopsyCytomegalovirusDNA, ViralFemaleHerpesviridaeHerpesviridae InfectionsHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 7, HumanHerpesvirus 8, HumanHumansIntestinesMaleMiddle AgedNasal MucosaNervous SystemThyroid GlandConceptsHHV-6Whole blood specimensHSV-1Lymph nodesHHV-7Nasal mucosaAnatomic sitesHuman herpesvirusesHIV-AIDSActive herpesvirus infectionHSV-1 positivitySalivary glandsMajor anatomic sitesMiddle-aged malesTime of deathCardiac arrestHHV-8Adrenal glandElderly malesPrimary infectionHSV-2Urinary bladderHerpesvirus infectionAnatomical mappingBone marrow
2005
Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils
Hudnall SD, Ge Y, Wei L, Yang NP, Wang HQ, Chen T. Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils. Modern Pathology 2005, 18: 519-527. PMID: 15696119, DOI: 10.1038/modpathol.3800369.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDB-LymphocytesChildChild, PreschoolEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmunohistochemistryImmunophenotypingMaleMiddle AgedPalatine TonsilT-LymphocytesViral Matrix ProteinsViral ProteinsConceptsEpstein-Barr virusEBER-positive cellsT cellsHuman tonsilsNK cellsPlasma cellsEpithelial cellsB cellsBiology of EBVNK/T-cell lymphomaEpstein-Barr virus-infected cellsEBV latent protein EBNA1CD20-positive B cellsCD3-positive T cellsEarly Protein BZLF1Non-B cell typeNatural killer cellsRare T cellsT-cell lymphomaLMP1-positive cellsVirus-infected cellsMost tonsilsPlasmacytoid morphologyKiller cellsInterfollicular zones
2004
Hematologic differences in heterophile‐positive and heterophile‐negative infectious mononucleosis
Ventura KC, Hudnall SD. Hematologic differences in heterophile‐positive and heterophile‐negative infectious mononucleosis. American Journal Of Hematology 2004, 76: 315-318. PMID: 15282662, DOI: 10.1002/ajh.20119.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAnimalsAntibodies, HeterophileCattleChildChild, PreschoolCross ReactionsFemaleHerpesvirus 4, HumanHumansInfectious MononucleosisLatex Fixation TestsLeukocyte CountLeukopeniaLymphocyte CountLymphocytesLymphocytosisMaleMiddle AgedRetrospective StudiesConceptsEBV-positive patientsEBV-negative patientsAbsolute lymphocyte countInfectious mononucleosisAtypical lymphocytosisLymphocyte countEpstein-Barr virus infectionEBV-negative casesEBV-negative groupTotal WBC countAgglutination test resultsAtypical lymphocytesAbsolute lymphocytosisBlood countLeukocyte countWBC countHematologic parametersVirus infectionMononucleosisHematologic differencesPatientsLymphocytosisEBVCountCauseSpecies identification of all eight human herpesviruses with a single nested PCR assay
Hudnall SD, Chen T, Tyring SK. Species identification of all eight human herpesviruses with a single nested PCR assay. Journal Of Virological Methods 2004, 116: 19-26. PMID: 14715303, DOI: 10.1016/j.jviromet.2003.10.005.Peer-Reviewed Original ResearchMeSH KeywordsCytomegalovirusDNA PrimersDNA-Directed DNA PolymeraseElectrophoretic Mobility Shift AssayHerpesviridaeHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 7, HumanHerpesvirus 8, HumanHeteroduplex AnalysisHumansNucleic Acid HybridizationPolymerase Chain ReactionConceptsHuman herpesvirusesPolymerase chain reactionHHV-6 subtypesClinical materialSignificant morbidityViral culturePrimary infectionLatent persistenceMultiple herpesvirusesChemiluminescent dot blot hybridizationChain reactionHeteroduplex mobilityHuman hostHerpesvirus detectionDot blot hybridizationHerpesvirusHerpesvirus DNA polymerase gene
2003
Human herpesvirus 8 seroprevalence and viral load in healthy adult blood donors
Hudnall SD, Chen T, Rady P, Tyring S, Allison P. Human herpesvirus 8 seroprevalence and viral load in healthy adult blood donors. Transfusion 2003, 43: 85-90. PMID: 12519435, DOI: 10.1046/j.1537-2995.2003.00272.x.Peer-Reviewed Original ResearchConceptsHHV-8 seroprevalenceBlood donorsDonor bloodPrimary effusion B-cell lymphomaABO blood group BHigh HHV-8 seroprevalenceHuman herpesvirus 8 seroprevalenceLatent HHV-8 antigensHealthy adult blood donorsBlood donor unitsBuffy coat DNAHHV-8 antigensHHV-8 ORF26HHV-8 viremiaSensitive indirect immunofluorescenceGeometric mean titersAdult blood donorsHHV-8 antibodiesHHV-8 DNABlood-borne virusesHuman herpesvirus 8B-cell lymphomaBlood group BDonor blood samplesHuman tumor virus
2001
Persistent Productive Epstein-Barr Virus Replication in Normal Epithelial Cells In Vivo
Walling D, Flaitz C, Nichols C, Hudnall S, Adler-Storthz K. Persistent Productive Epstein-Barr Virus Replication in Normal Epithelial Cells In Vivo. The Journal Of Infectious Diseases 2001, 184: 1499-1507. PMID: 11740724, DOI: 10.1086/323992.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusEpstein-Barr virus replicationHairy leukoplakiaEBV replicationValacyclovir treatmentVirus replicationNormal tongue tissuesPersistent EBV infectionProductive EBV replicationReverse transcriptase-polymerase chain reaction amplificationOral hairy leukoplakiaEpithelial cellsOral epithelial lesionsTongue epithelial cellsEBV infectionNormal epithelial cellsEBV DNAImmunodeficiency virusBiopsy specimensEpithelial lesionsImmunohistochemical detectionLeukoplakiaPolymerase chain reaction amplificationTongue tissueChain reaction amplificationGenetic Polymorphism (G80A) of Reduced Folate Carrier Gene in Ethnic Populations
Rady P, Szucs S, Matalon R, Grady J, Hudnall S, Kellner L, Nitowsky H. Genetic Polymorphism (G80A) of Reduced Folate Carrier Gene in Ethnic Populations. Molecular Genetics And Metabolism 2001, 73: 285-286. PMID: 11461197, DOI: 10.1006/mgme.2001.3197.Peer-Reviewed Original ResearchComposite nodular lymphocyte-predominance Hodgkin disease and gamma-heavy-chain disease: a case report and review of the literature.
Hudnall S, Alperin J, Petersen J. Composite nodular lymphocyte-predominance Hodgkin disease and gamma-heavy-chain disease: a case report and review of the literature. Archives Of Pathology & Laboratory Medicine 2001, 125: 803-7. PMID: 11371236, DOI: 10.5858/2001-125-0803-cnlphd.Peer-Reviewed Original ResearchConceptsNodular lymphocyte predominance Hodgkin's diseaseLymphocyte predominance Hodgkin's diseaseHodgkin's diseaseChain diseaseAutoimmune hemolytic anemiaB-cell natureB-cell lymphoproliferative processesComplete remissionGraves' diseaseLymph nodesCase reportLymphoproliferative processMonoclonal gammopathyHemolytic anemiaBone marrowUnique caseDiseaseClonal relationshipFurther treatment
2000
CD13-positive anaplastic large cell lymphoma of T-cell origin--a diagnostic and histogenetic problem.
Popnikolov N, Payne D, Hudnall S, Hawkins H, Kumar M, Norris B, Elghetany M. CD13-positive anaplastic large cell lymphoma of T-cell origin--a diagnostic and histogenetic problem. Archives Of Pathology & Laboratory Medicine 2000, 124: 1804-8. PMID: 11100061, DOI: 10.5858/2000-124-1804-cpalcl.Peer-Reviewed Original ResearchConceptsExtramedullary myeloid cell tumorAnaplastic large cell lymphomaT-cell originLarge cell lymphomaHistiocytic tumorsCell lymphomaCD30-positive anaplastic large cell lymphomaFlow cytometryExpression of CD13Complete remissionExtranodal sitesCytoplasmic CD3HLA-DRPrognostic implicationsCell tumorsDifferential diagnosisHistiocytic originHistogenetic problemsSurface antigenCD13 expressionVacuolated cytoplasmMalignant transformationCell expressionTumorsSurface markersMeasurement of estrogen receptors in intact cells by flow cytometry
Cao S, Hudnall S, Kohen F, Lu L. Measurement of estrogen receptors in intact cells by flow cytometry. Cytometry 2000, 41: 109-114. PMID: 11002266, DOI: 10.1002/1097-0320(20001001)41:2<109::aid-cyto5>3.0.co;2-7.Peer-Reviewed Original ResearchConceptsAnti-ER antibodiesDirect immunofluorescenceFlow cytometryIndirect immunofluorescenceEstrogen receptor levelsBreast cancer patientsER-negative MDAOutcome of treatmentHuman breast cancer cells MCF-7Anti-idiotypic antibodiesBreast cancer cells MCF-7Cancer cells MCF-7Flow cytometric analysisER immunostainingCells MCF-7Cancer patientsReceptor levelsEstrogen receptorER antibodyIntracellular antigensCytometric analysisTreatment of cellsTumor cellsAntibody clonesAntibodiesAcute myeloid leukemia associated with hemophagocytic syndrome and t(4;7)(q21;q36)
Kumar M, Boggino H, Hudnall S, Velagaleti G. Acute myeloid leukemia associated with hemophagocytic syndrome and t(4;7)(q21;q36). Cancer Genetics 2000, 122: 26-29. PMID: 11104028, DOI: 10.1016/s0165-4608(00)00268-5.Peer-Reviewed Original ResearchConceptsCases of HPSHemophagocytic syndromeMyeloid leukemiaClinical significanceMalignant processHematological malignanciesAcute myeloid leukemiaClonal karyotypic abnormalitiesClonal abnormalitiesFurther clonal evolutionKaryotypic abnormalitiesMalignancyNonclonal abnormalitiesAbnormalitiesClonal evolutionSyndromeLeukemiaCytogenetic studiesMicroscopic evidencePrognosisReactive processInfectionDiagnosisCasesGLUT-3 expression in human skeletal muscle
Stuart C, Wen G, Peng B, Popov V, Hudnall S, Campbell G. GLUT-3 expression in human skeletal muscle. AJP Endocrinology And Metabolism 2000, 279: e855-e861. PMID: 11001768, DOI: 10.1152/ajpendo.2000.279.4.e855.Peer-Reviewed Original ResearchMeSH KeywordsAdultFluorescent Antibody TechniqueGlucose Transporter Type 3HumansImmunohistochemistryIn Situ HybridizationMonosaccharide Transport ProteinsMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchMuscle, SkeletalNADH Tetrazolium ReductaseNerve Tissue ProteinsPeripheral NervesRNA, MessengerSarcoplasmic ReticulumSpinal NervesConceptsSlow-twitch muscle fibersHuman skeletal muscleGLUT-3Peripheral nervesSchwann cellsMuscle fibersAffinity-purified primary antibodiesSkeletal muscleHuman peripheral nervesGLUT-3 mRNANADH-tetrazolium reductase stainingGLUT-3 expressionGLUT-3 proteinNormal human skeletal muscleElectron microscopic evaluationFast-twitch fibersFluorescent-tagged antibodiesBiopsy homogenatesGLUT-1 proteinNerve cellsNerveMicroscopic evaluationAffinity-purified antibodiesAntibodiesMuscle sectionsMarked Increase in L-Selectin–Negative T Cells in Neonatal Pertussis
Hudnall S, Molina C. Marked Increase in L-Selectin–Negative T Cells in Neonatal Pertussis. American Journal Of Clinical Pathology 2000, 114: 35-40. PMID: 10884797, DOI: 10.1309/banx-8jkm-tuqn-4d6p.Peer-Reviewed Original ResearchConceptsPeripheral blood lymphocytesL-selectin expressionT cellsBlood lymphocytesNormal CD4/CD8 ratioCD4/CD8 ratioNaïve T cellsDetailed immunophenotypeNeonatal pertussisCD8 ratioMarked lymphocytosisNK cellsHealthy newbornsHLA-DRLymphoid tissueCord bloodT lymphocytesPertussis toxinB cellsL-selectinLymphocytesFlow cytometryPertussisMarked increaseDramatic findingKikuchi-Fujimoto Disease
Hudnall S. Kikuchi-Fujimoto Disease. American Journal Of Clinical Pathology 2000, 113: 761-764. PMID: 10874874, DOI: 10.1309/n4e2-78v9-qtfh-x4ff.Peer-Reviewed Original ResearchFulminant parvovirus infection following erythropoietin treatment in a patient with acquired immunodeficiency syndrome.
Borkowski J, Amrikachi M, Hudnall S. Fulminant parvovirus infection following erythropoietin treatment in a patient with acquired immunodeficiency syndrome. Archives Of Pathology & Laboratory Medicine 2000, 124: 441-5. PMID: 10705404, DOI: 10.5858/2000-124-0441-fpifet.Peer-Reviewed Original ResearchConceptsAcquired Immunodeficiency SyndromeBone marrow biopsyChronic anemiaImmunodeficiency syndromeMarrow biopsyReticulocyte responseParvovirus infectionErythroid aplasiaSecond bone marrow biopsyHuman parvovirus infectionSevere chronic anemiaIntravenous immunoglobulinErythropoietin treatmentErythroid hyperplasiaErythropoietin administrationRapid correctionHistologic examinationAnemiaInfectious naturePatientsInfectionBiopsyAplasiaSyndromeBlack menDifferential Expression of the HHV-8 vGCR Cellular Homolog Gene in AIDS-Associated and Classic Kaposi's Sarcoma: Potential Role of HIV-1 Tat
Yen-Moore A, Hudnall S, Rady P, Wagner R, Moore T, Memar O, Hughes T, Tyring S. Differential Expression of the HHV-8 vGCR Cellular Homolog Gene in AIDS-Associated and Classic Kaposi's Sarcoma: Potential Role of HIV-1 Tat. Virology 2000, 267: 247-251. PMID: 10662620, DOI: 10.1006/viro.1999.0125.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeCyclin DCyclinsGene Expression Regulation, ViralGene Products, tatHerpesvirus 8, HumanHIV-1HumansLeukocytes, MononuclearOncogenesReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionRNASarcoma, KaposiTat Gene Products, Human Immunodeficiency VirusTetradecanoylphorbol AcetateTumor Cells, CulturedViral ProteinsConceptsHIV-1 TatClassic Kaposi's sarcomaKaposi's sarcomaPeripheral blood mononuclear cellsAIDS-KS tissueBlood mononuclear cellsReverse transcriptase-polymerase chain reactionHuman herpesvirus 8Positive lymphoma cellsHHV-8 genesInterferon regulatory factor 1AIDS-associatedInflammatory proteinMononuclear cellsPolymerase chain reactionInterleukin-6Herpesvirus 8Regulatory factor 1SarcomaAngiogenic effectsLymphoma cellsBcl-2Factor 1Chain reactionPotential role