1996
Cytotoxic γδ T Lymphocytes Associated with an Epstein–Barr Virus-Induced Posttransplantation Lymphoproliferative Disorder
Rothenberg M, Weber W, Longtine J, Hafler D. Cytotoxic γδ T Lymphocytes Associated with an Epstein–Barr Virus-Induced Posttransplantation Lymphoproliferative Disorder. Clinical Immunology 1996, 80: 266-272. PMID: 8811046, DOI: 10.1006/clin.1996.0122.Peer-Reviewed Original ResearchConceptsGamma delta T cellsDelta T cellsGamma delta T-cell receptorDelta T-cell receptorPosttransplantation lymphoproliferative diseaseT cellsBrain lesionsT cell receptorLymphoproliferative diseaseCell receptorInflammatory brain lesionsPosttransplantation lymphoproliferative disorderEpstein-Barr virusCultured T cell linesCentral nervous systemT cell linesHuman brain tissueLymphoproliferative disordersAutoimmune diseasesInflammatory processVirus immunityNervous systemBrain tissueLesionsTarget cells
1995
Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements.
Stinissen P, Vandevyver C, Medaer R, Vandegaer L, Nies J, Tuyls L, Hafler DA, Raus J, Zhang J. Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. The Journal Of Immunology 1995, 154: 4883-94. PMID: 7722338, DOI: 10.4049/jimmunol.154.9.4883.Peer-Reviewed Original ResearchConceptsGamma delta T cell clonesGamma delta T cellsDelta T cellsT cell clonesGamma delta clonesMultiple sclerosisPeripheral bloodT cellsCerebrospinal fluidMS patientsOND patientsCell clonesControl subjectsNormal individualsBacterial superantigen staphylococcal enterotoxin BCentral nervous system demyelinationCSF of patientsSuperantigen staphylococcal enterotoxin BToxic shock syndrome toxin-1Nervous system demyelinationClonal originSecondary inflammatory processesV gene usageSyndrome toxin-1Staphylococcal enterotoxin B
1993
Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells.
Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. Journal Of Experimental Medicine 1993, 177: 425-432. PMID: 8093893, PMCID: PMC2190895, DOI: 10.1084/jem.177.2.425.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCD4-Positive T-LymphocytesClone CellsGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorHumansLiverMolecular Sequence DataOligodeoxyribonucleotidesReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsConceptsGamma/delta T cellsGamma/delta T cell clonesDelta T cellsT cell clonesGamma/delta T cell populationsT cell populationsT cellsFetal liverT cell developmentCell clonesCD4-CD8TCR delta chain transcriptsUnusual T-cell populationCell populationsFetal immune systemDelta-chain transcriptsGene rearrangementsT-cell receptor gammaGamma chain rearrangementT-cell receptor deltaHuman fetal liverTCR delta chainCell developmentAlpha/betaFetal thymus
1988
Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody.
Borst J, van Dongen JJ, Bolhuis RL, Peters PJ, Hafler DA, de Vries E, van de Griend RJ. Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody. Journal Of Experimental Medicine 1988, 167: 1625-1644. PMID: 2966845, PMCID: PMC2188932, DOI: 10.1084/jem.167.5.1625.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, MonoclonalAntigens, Differentiation, T-LymphocyteChildCytotoxicity, ImmunologicHumansNeoplasm ProteinsReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesTumor Cells, CulturedConceptsTCR gamma/deltaT lymphocytesPeripheral bloodHuman TCR-gamma/deltaT cell receptor gamma/deltaGrowth factorGamma/deltaViable T cellsT cell clonesDistinct immune functionsTarget cell recognitionDifferent receptor typesHuman T lymphocytesCD8 antigenDelta antibodyIL-2Murine T lymphocytesT cellsCell surface iodinationCytolytic activityImmune functionReceptor typesLymphocytesTCR moleculesNormal individuals