2023
High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq
Liu Y, DiStasio M, Su G, Asashima H, Enninful A, Qin X, Deng Y, Nam J, Gao F, Bordignon P, Cassano M, Tomayko M, Xu M, Halene S, Craft J, Hafler D, Fan R. High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq. Nature Biotechnology 2023, 41: 1405-1409. PMID: 36823353, PMCID: PMC10567548, DOI: 10.1038/s41587-023-01676-0.Peer-Reviewed Original Research
2008
TIM-4 Expressed on APCs Induces T Cell Expansion and Survival
Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 Expressed on APCs Induces T Cell Expansion and Survival. The Journal Of Immunology 2008, 180: 4706-4713. PMID: 18354194, PMCID: PMC2948965, DOI: 10.4049/jimmunol.180.7.4706.Peer-Reviewed Original Research
2004
4 Molecular Mimicry in Multiple Sclerosis Role of MHC-Altered Peptide Ligands (MAPL)
Lim D, Hafler D. 4 Molecular Mimicry in Multiple Sclerosis Role of MHC-Altered Peptide Ligands (MAPL). 2004, 45-55. PMCID: PMC7151874, DOI: 10.1016/b978-044451271-0.50004-1.Peer-Reviewed Original ResearchMicrobial peptidesMolecular mimicryMimicry hypothesisMolecular mechanismsMultiple sclerosisMolecular mimicry hypothesisDisease entityMajor pathogenic mechanismAttractive hypothesisMimicryPeptide ligandsMyelin proteinsSingle disease entityPathogenic mechanismsMultiple sclerosis lesionsCross-reacting antigenDirect evidenceDisease stageT cellsPeptidesSclerosis lesionsProteinDifferent disordersImmunological studiesMechanism
1993
Biological activity of recombinant human myelin basic protein
Oettinger H, Al-Sabbagh A, Jingwu Z, LaSalle J, Weiner H, Hafler D. Biological activity of recombinant human myelin basic protein. Journal Of Neuroimmunology 1993, 44: 157-162. PMID: 7685037, DOI: 10.1016/0165-5728(93)90037-y.Peer-Reviewed Original ResearchConceptsRecombinant human myelin basic proteinRecombinant protein bindsRecombinant MBPInducible expression vectorBasic proteinMyelin basic proteinRecombinant protein preparationsProtein bindsHuman myelin basic proteinRecombinant proteinsExpression vectorEscherichia coliProtein preparationsProteinNative MBPE. coliCation exchange chromatographySDS-PAGEBiological reagentsSimilar affinityHuman MBPColiBiological activitySimilar conformationsCell clones