Autoimmunity risk alleles in costimulation pathways
Maier LM, Hafler DA. Autoimmunity risk alleles in costimulation pathways. Immunological Reviews 2009, 229: 322-336. PMID: 19426231, DOI: 10.1111/j.1600-065x.2009.00777.x.Peer-Reviewed Original ResearchConceptsTumor necrosis factorGenome-wide association scansHuman autoimmune diseasesAutoimmune diseasesCommon human autoimmune diseasesInducible T-cell costimulator ligandGenetic study designsAssociation scanImmune related genesRelated genesCytotoxic T-lymphocyte antigen-4T-lymphocyte antigen-4Common autoimmune diseaseCell death 1Allelic variantsMember 15Environmental risk factorsDrug designCostimulatory mechanismsMember 4PathwayGenesCostimulation pathwayDeath-1Common pathway