2024
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis
Ogino N, Leite M, Guerra M, Kruglov E, Asashima H, Hafler D, Ito T, Pereira J, Peiffer B, Sun Z, Ehrlich B, Nathanson M. Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis. Journal Of Clinical Investigation 2024, 134: e171691. PMID: 38916955, PMCID: PMC11324315, DOI: 10.1172/jci171691.Peer-Reviewed Original ResearchAlcohol-associated hepatitisReduced cell proliferationCalcium channel expressionCalcium signaling mechanismsIntracellular calcium channelsCell proliferationRegulate calcium signalingNeutrophil extracellular trapsChannel expressionNeutrophil granule proteinsCalcium channelsNeutrophil infiltrationPatient specimensGranule proteasesMouse modelHealthy subjectsLiver diseaseExtracellular trapsCalcium signalingSerpin E2NeutrophilsElastase activityHepatitisTissue remodelingSignaling mechanisms
2014
Identification of Pathogenic IL-17 Producing FOXP3+ Tregs in Patients With De Novo Autoimmune Hepatitis.
Ekong U, Hill M, Edmunds C, Han G, Bhela S, Hafler D, Kleinewietfeld M. Identification of Pathogenic IL-17 Producing FOXP3+ Tregs in Patients With De Novo Autoimmune Hepatitis. Transplantation 2014, 98: 872-873. DOI: 10.1097/00007890-201407151-02977.Peer-Reviewed Original Research