2015
PAK6 targets to cell–cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape
Morse EM, Sun X, Olberding JR, Ha BH, Boggon TJ, Calderwood DA. PAK6 targets to cell–cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape. Journal Of Cell Science 2015, 129: 380-393. PMID: 26598554, PMCID: PMC4732285, DOI: 10.1242/jcs.177493.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigens, CDCadherinsCdc42 GTP-Binding ProteinCell AdhesionCell Line, TumorEpithelial CellsHEK293 CellsHumansIntercellular JunctionsMolecular Sequence DataP21-Activated KinasesProtein BindingProtein Interaction Domains and MotifsProtein Sorting SignalsProtein TransportConceptsCell-cell adhesionN-terminusCdc42/Rac interactive binding (CRIB) domainSerine/threonine kinaseP21-activated kinase (PAK) familyCdc42-dependent mannerPolybasic regionThreonine kinaseCdc42 knockdownKinase familyBinding domainsKinase activityImportant regulatorCell adhesionPAK6Broader rolePAKAdhesionTargetingCdc42PAK1KinaseKnockdownRegulatorMutations
2001
Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain*
Yan B, Calderwood D, Yaspan B, Ginsberg M. Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain*. Journal Of Biological Chemistry 2001, 276: 28164-28170. PMID: 11382782, DOI: 10.1074/jbc.m104161200.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsAntigens, CDBiotinBlood PlateletsCalpainCytoplasmCytoskeletonDNA, ComplementaryDose-Response Relationship, DrugGas Chromatography-Mass SpectrometryHumansIntegrin beta3IntegrinsKineticsMolecular Sequence DataPlatelet Membrane GlycoproteinsProtein BindingProtein Structure, TertiaryRatsRecombinant ProteinsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSurface Plasmon ResonanceTalinTime Factors
2000
Distinct Domains of CD98hc Regulate Integrins and Amino Acid Transport*
Fenczik C, Zent R, Dellos M, Calderwood D, Satriano J, Kelly C, Ginsberg M. Distinct Domains of CD98hc Regulate Integrins and Amino Acid Transport*. Journal Of Biological Chemistry 2000, 276: 8746-8752. PMID: 11121428, DOI: 10.1074/jbc.m011239200.Peer-Reviewed Original ResearchConceptsAmino acid transportIntegrin functionAcid transportDistinct domainsType II transmembrane proteinIsoleucine transportAmino acid transportersCD98 heavy chainCell surface heterodimersTransmembrane domainCytoplasmic domainTransmembrane proteinSurface heterodimersExtracellular domainAcid transportersCD98hcHeavy chainProteinIntegrinsCovalent linkageDifferent light chainsLight chainDomainMutantsHeterodimersClass- and Splice Variant-specific Association of CD98 with Integrin β Cytoplasmic Domains*
Zent R, Fenczik C, Calderwood D, Liu S, Dellos M, Ginsberg M. Class- and Splice Variant-specific Association of CD98 with Integrin β Cytoplasmic Domains*. Journal Of Biological Chemistry 2000, 275: 5059-5064. PMID: 10671548, DOI: 10.1074/jbc.275.7.5059.Peer-Reviewed Original ResearchConceptsCytoplasmic domainIntegrin activationMuscle-specific splice variantIntegrin beta cytoplasmic domainsBasic amino acid transportType II transmembrane proteinIntegrin β cytoplasmic domainBeta cytoplasmic domainsIntegrin cytoplasmic domainCell fusion eventsIntegrin adhesion receptorsAmino acid transportTransmembrane proteinMembrane proteinsFusion eventsIntegrin classAdhesion receptorsSplice variantsAcid transportCD98Variant specificityProteinIntegrinsDomainActivation
1997
The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin*
Calderwood D, Tuckwell D, Eble J, Kühn K, Humphries M. The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin*. Journal Of Biological Chemistry 1997, 272: 12311-12317. PMID: 9139675, DOI: 10.1074/jbc.272.19.12311.Peer-Reviewed Original Research
1995
Integrin α2 I-domain is a binding site for collagens
Tuckwell D, Calderwood D, Green L, Humphries M. Integrin α2 I-domain is a binding site for collagens. Journal Of Cell Science 1995, 108: 1629-1638. PMID: 7615681, DOI: 10.1242/jcs.108.4.1629.Peer-Reviewed Original ResearchConceptsAlpha 2 beta 1Alpha 1 beta 1I-domainIntegrin alpha 2 beta 1Beta 1N-terminal regionMajor cellular receptorAlpha 2 subunitIntegrins alpha 1 beta 1Complete receptorBacterial expressionAnti-functional antibodiesCollagen-binding domainA-domainInhibits cellAmino acidsCollagen specificityCellular receptorsXI collagenConcentration-dependent mannerVon Willebrand factorAlpha 1BindingWillebrand factorHomology