2004
Talin controls integrin activation
Calderwood DA. Talin controls integrin activation. Biochemical Society Transactions 2004, 32: 434-437. PMID: 15157154, DOI: 10.1042/bst0320434.Peer-Reviewed Original ResearchConceptsIntegrin beta tailsIntegrin activationCytoplasmic domainBeta tailsMajor actin-binding proteinIntegrin beta cytoplasmic domainsBeta cytoplasmic domainsIntegrin cytoplasmic domainIntegrin activation pathwaysCytoskeletal protein talinIntegrin extracellular domainActin-binding proteinsIntegrin adhesion receptorsBinding of talinTalin FERM domainIntegrin-binding siteMulticellular organismsPTB domainFERM domainProtein talinExtracellular ligandsTalin expressionRNA interferenceTalinIntracellular signals
1999
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*
Calderwood D, Zent R, Grant R, Rees D, Hynes R, Ginsberg M. The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*. Journal Of Biological Chemistry 1999, 274: 28071-28074. PMID: 10497155, DOI: 10.1074/jbc.274.40.28071.Peer-Reviewed Original ResearchConceptsTalin head domainIntegrin cytoplasmic tailsCytoplasmic tailIntegrin-binding siteHead domainActin cytoskeletonFragment of talinIntegrin beta tailsIntegrin adhesion receptorsSingle point mutationFocal adhesionsCytoplasmic domainCytoplasmic proteinsBeta tailsIntegrin functionIntegrin localizationTalinIntegrin activationIntegrin affinityActin filamentsAdhesion receptorsIntegrin-cytoskeletal interactionsPoint mutationsCytoskeletonStructural mimics