2012
Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures
Saw YT, Yang J, Ng SK, Liu S, Singh S, Singh M, Welch WR, Tsuda H, Fong WP, Thompson D, Vasiliou V, Berkowitz RS, Ng SW. Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures. BMC Cancer 2012, 12: 329. PMID: 22852552, PMCID: PMC3458927, DOI: 10.1186/1471-2407-12-329.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseClinical Enzyme TestsFemaleHumansImmunohistochemistryIsoenzymesOvarian NeoplasmsSpheroids, CellularTumor Cells, CulturedConceptsClear cell tumorsWestern blot analysisCell tumorsOvarian tissueALDH isozymesCancer cellsClear cell subtypeSphere cultureOvarian cancer tissuesQuantitative reverse transcription polymerase chain reactionNormal ovarian tissuesOvarian epithelial tumorsReverse transcription-polymerase chain reactionHuman ovarian cancerOvarian tumor tissuesTranscription-polymerase chain reactionOvarian cancer cellsBlot analysisHuman cancer stem cellsCancer stem cellsOvarian cancer pathophysiologyMRNA expression levelsResultsImmunohistochemical stainingCancer cell linesMucinous tumors
2011
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer
Chen Y, Orlicky DJ, Matsumoto A, Singh S, Thompson DC, Vasiliou V. Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. Biochemical And Biophysical Research Communications 2011, 405: 173-179. PMID: 21216231, PMCID: PMC3112362, DOI: 10.1016/j.bbrc.2011.01.002.Peer-Reviewed Original ResearchConceptsHuman colon cancerColon cancerPotential biomarkersLipid peroxidationHigher expression scoresHuman cancersAldehyde dehydrogenase 1B1Cancer stem cellsColonic cancer specimensHuman colonic adenocarcinomaColonic adenocarcinomaImmunohistochemical expressionCancer specimensActivity of ALDHTumor tissueExpression scoreHuman adenocarcinomasTissue arraysAdenocarcinomaALDH activityCancerALDH1A1ALDH isozymesCancerous tissuesStem cells
2000
Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells
Koffler L, Roshong S, Park I, Cesen‐Cummings K, Thompson D, Dwyer‐Nield L, Rice P, Mamay C, Malkinson A, Ruch R. Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells. Journal Of Cellular Biochemistry 2000, 79: 347-354. PMID: 10972973, DOI: 10.1002/1097-4644(20001201)79:3<347::aid-jcb10>3.0.co;2-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinomaCell CommunicationCell Cycle ProteinsCell DivisionConnexinsCyclin D1Cyclin-Dependent Kinase Inhibitor p27CytokinesDiffusionFluorescent DyesG1 PhaseGap JunctionsGene Expression Regulation, NeoplasticLiver Neoplasms, ExperimentalLung NeoplasmsMiceMicrotubule-Associated ProteinsNeoplasm ProteinsNitric OxideProtein KinasesRatsReceptors, Growth FactorRecombinant Fusion ProteinsTransfectionTumor Cells, CulturedTumor Suppressor ProteinsConceptsGap junctional intercellular communicationRat liver epithelial cellsConnexin expressionE9 cellsLiver epithelial cellsGrowth controlDefective growth controlCyclin D1Growth-related functionsTransfection of Cx43Cell cycle regulatorsCell linesEpithelial cellsGap junction proteinCarcinoma cellsMouse lung carcinoma cellsJunctional intercellular communicationLess cyclin D1Cell cycle distributionCycle regulatorsForced expressionIntercellular communicationS phaseP27kip-1Lung carcinoma cells
1998
Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines
Thompson D, Porter S, Bauer A, Das K, Ou B, Dwyer-Nield L, White C, Malkinson A. Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines. American Journal Of Physiology 1998, 274: l922-l932. PMID: 9609731, DOI: 10.1152/ajplung.1998.274.6.l922.Peer-Reviewed Original ResearchConceptsLung epithelial cell lineEpithelial cell lineLung epithelial cellsNontumorigenic cellsCell linesMurine lung epithelial cell lineEpithelial cellsMurine lung epithelial cellsTumorigenic counterpartsMRNA stabilityE10 cellsTumorigenic cellsWestern blot analysisProtein synthesisNormal progenitor cellsCell's abilityINOS regulationNuclear factor-kappaB activationProgenitor cellsCytokine-induced NO synthesisSpontaneous transformantsBlot analysisInducible NO synthaseMurine linesTransformation alters